PROGNOSTIC FACTORS OF POSITIVE RESULTS OF MULTIFOCAL TRUS-GUIDED VESICOURETHRAL ANASTOMOSIS BIOPSY IN PATIENTS WITH BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY

<p><strong>Purpose. </strong>To evaluate influence of clinical, biochemical and histological factors to detection rate of local recurrence following radical prostatectomy (RPE) using multifocal TRUS-guided vesicourethral anastomosis (VUA) biopsy.</p><p><strong>Material and methods. </strong>59 patients with newly diagnosed biochemical recurrence (BR) after RPE were included into prospective study. All of them underwent multifocal TRUS-guided VUA biopsy. Сlinical variables (serum prostate-specifi c antigen [PSA] level and PSA kinetics, time RPE-BR, Gleason grade, stage after RPE and clinical findings) were evaluated. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed.</p><p><strong>Results. </strong>The detection rate of local prostate recurrence with TRUS-guided VUA biopsy was 45,8 % (95 % CI 33,7–58,3). At multivariate analysis only PSA level at the moment of biopsy (≤ 1,5 ng/ml vs &gt; 1,5 ng/ml) and time RPE-BR (≤ 15 months vs &gt; 15 months) were significantly associated with positive results of multifocal TRUS-guided VUA biopsy (p &lt; 0,05).</p><p><strong>Conclusion </strong>The detection rate of local prostate recurrence with TRUS-guided VUA biopsy depends on combination of independent predictors (PSA level at the moment of biopsy and time RPE—BR).