In vascular biology, endothelial KCa2.3 and KCa3.1 channels contribute to arterial blood pressure regulation by producing membrane hyperpolarization and smooth muscle relaxation. The role of KCa2.3 and KCa3.1 channels in the pulmonary circulation is not fully established. Using mice with genetically encoded deficit of KCa2.3 and KCa3.1 channels, this study investigated the effect of loss of the channels in hypoxia-induced pulmonary hypertension.Male wild type and KCa3.1-/-/KCa2.3T/T(+DOX) mice were exposed to chronic hypoxia for four weeks to induce pulmonary hypertension. The degree of pulmonary hypertension was evaluated by right ventricular pressure and assessment of right ventricular hypertrophy. Segments of pulmonary arteries were moun...
In pulmonary artery (PA), compelling evidence have suggested that TWIK-related Acid Sensitive K+ -1 ...
The cardiac hormone atrial natriuretic peptide (ANP) regulates systemic and pulmonary arterial blood...
Chronic hypoxia induces pulmonary hypertension and right ventricular (RV) hypertrophy. Nitric oxide ...
3.1 channels, this study investigated the effect of loss of the channels in hypoxia-induced pulmonar...
International audienceRationale: Pulmonary arterial hypertension is a severe lethal cardiopulmonary ...
RATIONALE: Hypoxic pulmonary vasoconstriction (HPV) is an important mechanism by which pulmonary gas...
Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 ...
IntroductionPulmonary hypertension (PH) carries significant associated morbidity and mortality and t...
International audienceAims BMP9 and BMP10 mutations were recently identified in patients with pulmon...
BACKGROUND: Chronic hypoxia results in the development of pulmonary hypertension and subsequent righ...
Background—Chronic hypoxia results in the development of pulmonary hypertension and subsequent right...
In pulmonary artery (PA), compelling evidence have suggested that TWIK-related Acid Sensitive K+ -1 ...
The cardiac hormone atrial natriuretic peptide (ANP) regulates systemic and pulmonary arterial blood...
Chronic hypoxia induces pulmonary hypertension and right ventricular (RV) hypertrophy. Nitric oxide ...
3.1 channels, this study investigated the effect of loss of the channels in hypoxia-induced pulmonar...
International audienceRationale: Pulmonary arterial hypertension is a severe lethal cardiopulmonary ...
RATIONALE: Hypoxic pulmonary vasoconstriction (HPV) is an important mechanism by which pulmonary gas...
Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 ...
IntroductionPulmonary hypertension (PH) carries significant associated morbidity and mortality and t...
International audienceAims BMP9 and BMP10 mutations were recently identified in patients with pulmon...
BACKGROUND: Chronic hypoxia results in the development of pulmonary hypertension and subsequent righ...
Background—Chronic hypoxia results in the development of pulmonary hypertension and subsequent right...
In pulmonary artery (PA), compelling evidence have suggested that TWIK-related Acid Sensitive K+ -1 ...
The cardiac hormone atrial natriuretic peptide (ANP) regulates systemic and pulmonary arterial blood...
Chronic hypoxia induces pulmonary hypertension and right ventricular (RV) hypertrophy. Nitric oxide ...