An integrated catalog of reference genes in the human gut microbiome
- Li, J.
- Jia, H.
- Cai, X.
- Zhong, H.
- Feng, Q.
- Sunagawa, S.
- Arumugam, M.
- Kultima, J.R.
- Prifti, E.
- Nielsen, T.
- Juncker, A.S.
- Manichanh, C.
- Chen, B.
- Zhang, W.
- Levenez, F.
- Xu, X.
- Xiao, L.
- Liang, S.
- Zhang, D.
- Zhang, Z.
- Chen, W.
- Zhao, H.
- Al-Aama, J.Y.
- Edris, S.
- Yang, H.
- Hansen, H.
- Nielsen, H.B.
- Brunak, S.
- Kristiansen, K.
- Guarner, F.
- Pedersen, O.
- Doré, J.
- Ehrlich, S.D.
- Bork, P.
- Wang, J.
- Vos, de, W.M.
- Tims, S.
- Zoetendal, E.G.
- Kleerebezem, M.
DOIAbstract
Many analyses of the human gut microbiome depend on a catalog of reference genes. Existing catalogs for the human gut microbiome are based on samples from single cohorts or on reference genomes or protein sequences, which limits coverage of global microbiome diversity. Here we combined 249 newly sequenced samples of the Metagenomics of the Human Intestinal Tract (MetaHit) project with 1,018 previously sequenced samples to create a cohort from three continents that is at least threefold larger than cohorts used for previous gene catalogs. From this we established the integrated gene catalog (IGC) comprising 9,879,896 genes. The catalog includes close-to-complete sets of genes for most gut microbes, which are also of considerably higher quali...
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