BACKGROUND: Human fetal midbrain-derived neural progenitor cells (NPCs) may deliver a tissue source for drug screening and regenerative cell therapy to treat Parkinson's disease. While glutamate and GABA(A) receptors play an important role in neurogenesis, the involvement of glycine receptors during human neurogenesis and dopaminergic differentiation as well as their molecular and functional characteristics in NPCs are largely unknown. METHODOLOGY/PRINCIPAL FINDINGS: Here we investigated NPCs in respect to their glycine receptor function and subunit expression using electrophysiology, calcium imaging, immunocytochemistry, and quantitative real-time PCR. Whole-cell recordings demonstrate the ability of NPCs to express functional strychnine-s...
Neurotransmitters play multiple roles in the development and maturation of the central nervous syst...
Glycine receptors (GlyRs) play a major role in the excitability of spinal cord and brain stem neuron...
Mouse embryonic stem (mES) cells possess a virtually unlimited differentiation potential and have be...
Multipotent neural stem and progenitor cells (NS/PCs) are well-established cell subpopulations occur...
Immunocytochemical analysis showed that ionotropic glycine receptors are expressed in neurogenic pro...
Using the whole-cell patch-clamp technique, we demonstrate glycine-induced currents in oligosphere-d...
The strychnine-sensitive glycine receptor (GlyR) is a member of the ligand-gated ion channel superfa...
The strychnine-sensitive glycine receptor (GlyR) is a member of the ligand-gated ion channel superfa...
The development of the cerebral cortex requires coordinated regulation of proliferation, specificati...
The development of the cerebral cortex is a complex process that requires the generation, migration,...
Neural progenitor is a generic term used for undifferentiated cell populations of neural stem, neuro...
The strychnine-sensitive glycine receptor (GlyR) is a member of the ligand-gated ion channel superfa...
This work addresses developmental regulation of neurotransmitter receptors in the vertebrate central...
In this review, we have summarized our recent studies on the functionality of ionotropic (iGluR) and...
Glycine receptors (GlyRs) are ligand-gated chloride ion channels that mediate fast inhibitory neurot...
Neurotransmitters play multiple roles in the development and maturation of the central nervous syst...
Glycine receptors (GlyRs) play a major role in the excitability of spinal cord and brain stem neuron...
Mouse embryonic stem (mES) cells possess a virtually unlimited differentiation potential and have be...
Multipotent neural stem and progenitor cells (NS/PCs) are well-established cell subpopulations occur...
Immunocytochemical analysis showed that ionotropic glycine receptors are expressed in neurogenic pro...
Using the whole-cell patch-clamp technique, we demonstrate glycine-induced currents in oligosphere-d...
The strychnine-sensitive glycine receptor (GlyR) is a member of the ligand-gated ion channel superfa...
The strychnine-sensitive glycine receptor (GlyR) is a member of the ligand-gated ion channel superfa...
The development of the cerebral cortex requires coordinated regulation of proliferation, specificati...
The development of the cerebral cortex is a complex process that requires the generation, migration,...
Neural progenitor is a generic term used for undifferentiated cell populations of neural stem, neuro...
The strychnine-sensitive glycine receptor (GlyR) is a member of the ligand-gated ion channel superfa...
This work addresses developmental regulation of neurotransmitter receptors in the vertebrate central...
In this review, we have summarized our recent studies on the functionality of ionotropic (iGluR) and...
Glycine receptors (GlyRs) are ligand-gated chloride ion channels that mediate fast inhibitory neurot...
Neurotransmitters play multiple roles in the development and maturation of the central nervous syst...
Glycine receptors (GlyRs) play a major role in the excitability of spinal cord and brain stem neuron...
Mouse embryonic stem (mES) cells possess a virtually unlimited differentiation potential and have be...