Recent analyses have revealed many functional microRNA (miRNA) targets in mammalian protein coding regions. But, the mechanisms that ensure miRNA function when their target sites are located in protein coding regions of mammalian mRNA transcripts are largely unknown. In this paper, we investigate some potential biological factors, such as target site accessibility and local translation efficiency. We computationally analyze these two factors using experimentally identified miRNA targets in human protein coding region. We find site accessibility is significantly increased in miRNA target region to facilitate miRNA binding. At the mean time, local translation efficiency is also selectively decreased near miRNA target region. GC-poor codons ar...
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression in plants and animals. Al...
MicroRNAs (miRNAs) have emerged as central post-transcriptional regulators of gene expression in hig...
MicroRNAs (miRNAs) are small RNA molecules that play important roles in gene regulation and translat...
<div><p>Recent analyses have revealed many functional microRNA (miRNA) targets in mammalian protein ...
With respect to upstream regions of microRNA (miRNA) target sites located in protein coding sequence...
Animal miRNAs are a large class of small regulatory RNAs that are known to directly and negatively r...
MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the message or...
<div><p>MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the me...
MicroRNAs (miRNAs) are small RNA molecules that play important roles in gene regulation and translat...
<div><p>MicroRNAs (miRNAs) are small RNA molecules that play important roles in gene regulation and ...
Abstract Background MicroRNAs are an important class of regulatory RNAs which repress animal genes b...
Animal miRNAs are a large class of small regulatory RNAs that are known to directly and negatively r...
BACKGROUND: MicroRNAs are an important class of regulatory RNAs which repress animal genes by prefer...
Motivation: Experimental evidence has accumulated showing that microRNA (miRNA) binding sites within...
MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby sile...
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression in plants and animals. Al...
MicroRNAs (miRNAs) have emerged as central post-transcriptional regulators of gene expression in hig...
MicroRNAs (miRNAs) are small RNA molecules that play important roles in gene regulation and translat...
<div><p>Recent analyses have revealed many functional microRNA (miRNA) targets in mammalian protein ...
With respect to upstream regions of microRNA (miRNA) target sites located in protein coding sequence...
Animal miRNAs are a large class of small regulatory RNAs that are known to directly and negatively r...
MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the message or...
<div><p>MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the me...
MicroRNAs (miRNAs) are small RNA molecules that play important roles in gene regulation and translat...
<div><p>MicroRNAs (miRNAs) are small RNA molecules that play important roles in gene regulation and ...
Abstract Background MicroRNAs are an important class of regulatory RNAs which repress animal genes b...
Animal miRNAs are a large class of small regulatory RNAs that are known to directly and negatively r...
BACKGROUND: MicroRNAs are an important class of regulatory RNAs which repress animal genes by prefer...
Motivation: Experimental evidence has accumulated showing that microRNA (miRNA) binding sites within...
MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby sile...
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression in plants and animals. Al...
MicroRNAs (miRNAs) have emerged as central post-transcriptional regulators of gene expression in hig...
MicroRNAs (miRNAs) are small RNA molecules that play important roles in gene regulation and translat...