Elevated expression levels of monocytic-ACE have been found in haemodialysis patients. They are not only epidemiologically linked with increased mortality and cardiovascular disease, but may also directly participate in the initial steps of atherosclerosis. To further address this question we tested the role of monocytic-ACE in promotion of atherosclerotic events in vitro under conditions mimicking those of chronic renal failure.Treatment of human primary monocytes or THP-1 cells with uremic serum as well as PMA-induced differentiation led to significantly up-regulated expression of ACE, further increased by additional treatment with LPS. Functionally, these monocytes revealed significantly increased adhesion and transmigration through endo...
Background and aims: Hyperuricemia is an important risk factor for atherosclerosis, yet the potentia...
Atherogenesis is dependent upon monocyte influx into the vessel wall. In humans, three monocyte subs...
Aims: Monocytes play an important role in hypertension. Circulating monocytes in humans exist as cla...
Elevated expression levels of monocytic-ACE have been found in haemodialysis patients. They are not ...
Aims: Elevated expression levels of monocytic-ACE have been found in haemodialysis patients. They ar...
<p>(A, B, C) Primary human monocytes obtained from healthy volunteers P1, P2, and P3 were treated wi...
<p>(A, B) Primary human monocytes obtained from healthy volunteer P1 were treated with (A) 10% NS or...
Intermediate (CD14(++)CD16(+)) monocytes have important pro-inflammatory and atherogenic features an...
The urokinase receptor (urokinase plasminogen activator receptor; uPAR) regulates monocyte adhesion ...
Objective The uremic toxin Indoxyl-3-sulphate (IS), a ligand of Aryl hydrocarbon Receptor (AhR), rai...
Atherosclerosis is currently viewed as a chronic inflammatory disease of the arterial vessel wall wi...
Despite the availability of effective therapy of hypercholesterolemia and hypertension, cardiovascul...
Despite improvements in interventional and pharmacological therapy of atherosclerotic disease, it is...
The potential regulatory effect of angiotensins on circulating mononuclear cell activation and migra...
Accumulation of classical monocytes is imperative for the progression ofatherosclerosis. Hence, ther...
Background and aims: Hyperuricemia is an important risk factor for atherosclerosis, yet the potentia...
Atherogenesis is dependent upon monocyte influx into the vessel wall. In humans, three monocyte subs...
Aims: Monocytes play an important role in hypertension. Circulating monocytes in humans exist as cla...
Elevated expression levels of monocytic-ACE have been found in haemodialysis patients. They are not ...
Aims: Elevated expression levels of monocytic-ACE have been found in haemodialysis patients. They ar...
<p>(A, B, C) Primary human monocytes obtained from healthy volunteers P1, P2, and P3 were treated wi...
<p>(A, B) Primary human monocytes obtained from healthy volunteer P1 were treated with (A) 10% NS or...
Intermediate (CD14(++)CD16(+)) monocytes have important pro-inflammatory and atherogenic features an...
The urokinase receptor (urokinase plasminogen activator receptor; uPAR) regulates monocyte adhesion ...
Objective The uremic toxin Indoxyl-3-sulphate (IS), a ligand of Aryl hydrocarbon Receptor (AhR), rai...
Atherosclerosis is currently viewed as a chronic inflammatory disease of the arterial vessel wall wi...
Despite the availability of effective therapy of hypercholesterolemia and hypertension, cardiovascul...
Despite improvements in interventional and pharmacological therapy of atherosclerotic disease, it is...
The potential regulatory effect of angiotensins on circulating mononuclear cell activation and migra...
Accumulation of classical monocytes is imperative for the progression ofatherosclerosis. Hence, ther...
Background and aims: Hyperuricemia is an important risk factor for atherosclerosis, yet the potentia...
Atherogenesis is dependent upon monocyte influx into the vessel wall. In humans, three monocyte subs...
Aims: Monocytes play an important role in hypertension. Circulating monocytes in humans exist as cla...