Association between Hlaantigens and Progression of HIV Infection in Greek Haemophiliacs

Chr. Papasteriades
J. Economidou
H. Pappas
K. Psarra
V. Kapsimali
K. Karafoulidou
T. Mandalaki
G. Papaevangelou

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Publication date

January 1993

DOI

10.1155/1993/674362

Publisher

Hindawi Limited

ISSN

0278-0240

Journal

1875-8630

Citation count (estimate)

Abstract

The frequencies of HLA antigens in 33 HIV seronegative and in 88 HIV seropositive haemophiliacs, who have been followed for at least 6 years since seroconversion or first HIV positive test. were evaluated in relation to disease susceptibility and disease progression. A high frequency of HLA-A2 and -DR2 antigens and a low frequency of HLA-A9 were found to characterize HIV seropositive patients (p<0.05). Progressors to symptomatic CDC stage IV had a higher frequency of HLA-A9 (p<0.01) and DR3. Rapid decline of CD4+ T cells in these patients was associated with HLA-A9, -DR I and DR3. Our data suggest that HLA antigens may contribute to susceptibility to HIV infection and disease progression in Greek haemophiliacs