Despite preclinical success in regenerating and revascularizing the infarcted heart using angiogenic growth factors or bone marrow (BM) cells, recent clinical trials have revealed less benefit from these therapies than expected.We explored the therapeutic potential of myocardial gene therapy of placental growth factor (PlGF), a VEGF-related angiogenic growth factor, with progenitor-mobilizing activity.Myocardial PlGF gene therapy improves cardiac performance after myocardial infarction, by inducing cardiac repair and reparative myoangiogenesis, via upregulation of paracrine anti-apoptotic and angiogenic factors. In addition, PlGF therapy stimulated Sca-1(+)/Lin(-) (SL) BM progenitor proliferation, enhanced their mobilization into peripheral...
Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family t...
SIGNIFICANCE: Proangiogenic therapy appeared a promising strategy for the treatment of patients with...
International audienceObjectivesWe studied whether plasma levels of angiogenic factors VEGF and plac...
Despite preclinical success in regenerating and revascularizing the infarcted heart using angiogenic...
Recent evidence indicates that an imbalance between cardiomyocyte hypertrophy and blood vessel growt...
ObjectivesOur aim was to investigate cardiac expression of placental growth factor (PlGF) and its cl...
Background/Aims: Transplantation of mesenchymal stem cells (MSCs) improves post-injury cardiac muscl...
Background: Autologous cells for cell therapy of ischemic cardiomyopathy often display age- and dise...
The therapeutic potential of placental growth factor (PlGF) and its receptor Flt1 in angiogenesis is...
ObjectivesThe purpose of this study was to investigate the role of plasminogen (Plg) in stem cell–me...
Studies have established that oxidative stress plays an important role in the pathology of myocardia...
Placental growth factor (PlGF) is a mitogen for endothelial cells, but it can also act as a proinfla...
Background - Growth factors play an essential role in organogenesis. We examine the potential of gro...
Background—Mesenchymal stem cell (MSC)-based regenerative strategies were investigated to treat acut...
Intravenous delivery of mesenchymal stem cells (MSCs) prepared from adult bone marrow reduces infarc...
Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family t...
SIGNIFICANCE: Proangiogenic therapy appeared a promising strategy for the treatment of patients with...
International audienceObjectivesWe studied whether plasma levels of angiogenic factors VEGF and plac...
Despite preclinical success in regenerating and revascularizing the infarcted heart using angiogenic...
Recent evidence indicates that an imbalance between cardiomyocyte hypertrophy and blood vessel growt...
ObjectivesOur aim was to investigate cardiac expression of placental growth factor (PlGF) and its cl...
Background/Aims: Transplantation of mesenchymal stem cells (MSCs) improves post-injury cardiac muscl...
Background: Autologous cells for cell therapy of ischemic cardiomyopathy often display age- and dise...
The therapeutic potential of placental growth factor (PlGF) and its receptor Flt1 in angiogenesis is...
ObjectivesThe purpose of this study was to investigate the role of plasminogen (Plg) in stem cell–me...
Studies have established that oxidative stress plays an important role in the pathology of myocardia...
Placental growth factor (PlGF) is a mitogen for endothelial cells, but it can also act as a proinfla...
Background - Growth factors play an essential role in organogenesis. We examine the potential of gro...
Background—Mesenchymal stem cell (MSC)-based regenerative strategies were investigated to treat acut...
Intravenous delivery of mesenchymal stem cells (MSCs) prepared from adult bone marrow reduces infarc...
Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family t...
SIGNIFICANCE: Proangiogenic therapy appeared a promising strategy for the treatment of patients with...
International audienceObjectivesWe studied whether plasma levels of angiogenic factors VEGF and plac...