Mutations in the giant sarcomeric protein titin (TTN) are a major cause for inherited forms of dilated cardiomyopathy (DCM). We have previously developed a mouse model that imitates a TTN truncation mutation we found in a large pedigree with DCM. While heterozygous Ttn knock-in mice do not display signs of heart failure under sedentary conditions, they recapitulate the human phenotype when exposed to the pharmacological stressor angiotensin II or isoproterenol. In this study we investigated the effects of pressure overload by transverse aortic constriction (TAC) in heterozygous (Het) Ttn knock-in mice. Two weeks after TAC, Het mice developed marked impairment of left ventricular ejection fraction (p<0.05), while wild-type (WT) TAC mice did ...
Rationale: The giant protein titin plays key roles in myofilament assembly and determines the passiv...
BACKGROUND: Titin is a giant protein crucial for the assembly and elasticity of the sarcomere. Recen...
Background Mutations in the human desmin gene (DES) cause autosomal-dominant and -recessive cardi...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Titin (TTN) Truncating variants (TTNtv) in the A-band of TTN predispose the mouse heart to systolic ...
Titin (TTN) Truncating variants (TTNtv) in the A-band of TTN predispose the mouse heart to systolic ...
Titin truncating variants are a well-established cause of cardiomyopathy; however, the role of titin...
Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are also encoun...
Human mutations that truncate the massive sarcomere protein titin [TTN-truncating variants (TTNtvs)]...
Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are also encoun...
Aim: Mutations in a sarcomeric protein can cause hypertrophic cardiomyopathy (HCM) or dilated cardio...
BACKGROUND:Mutations in the human desmin gene (DES) cause autosomal-dominant and -recessive cardiomy...
Rationale: The giant protein titin plays key roles in myofilament assembly and determines the passiv...
Hypertrophic (HCM) and dilated (DCM) cardiomyopathies result from sarcomeric protein mutations, incl...
Heterozygous truncating variants in TTN (TTNtv), the gene coding for titin, cause dilated cardiomyop...
Rationale: The giant protein titin plays key roles in myofilament assembly and determines the passiv...
BACKGROUND: Titin is a giant protein crucial for the assembly and elasticity of the sarcomere. Recen...
Background Mutations in the human desmin gene (DES) cause autosomal-dominant and -recessive cardi...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
Titin (TTN) Truncating variants (TTNtv) in the A-band of TTN predispose the mouse heart to systolic ...
Titin (TTN) Truncating variants (TTNtv) in the A-band of TTN predispose the mouse heart to systolic ...
Titin truncating variants are a well-established cause of cardiomyopathy; however, the role of titin...
Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are also encoun...
Human mutations that truncate the massive sarcomere protein titin [TTN-truncating variants (TTNtvs)]...
Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are also encoun...
Aim: Mutations in a sarcomeric protein can cause hypertrophic cardiomyopathy (HCM) or dilated cardio...
BACKGROUND:Mutations in the human desmin gene (DES) cause autosomal-dominant and -recessive cardiomy...
Rationale: The giant protein titin plays key roles in myofilament assembly and determines the passiv...
Hypertrophic (HCM) and dilated (DCM) cardiomyopathies result from sarcomeric protein mutations, incl...
Heterozygous truncating variants in TTN (TTNtv), the gene coding for titin, cause dilated cardiomyop...
Rationale: The giant protein titin plays key roles in myofilament assembly and determines the passiv...
BACKGROUND: Titin is a giant protein crucial for the assembly and elasticity of the sarcomere. Recen...
Background Mutations in the human desmin gene (DES) cause autosomal-dominant and -recessive cardi...