Modulation of extracellular matrix (ECM) remodeling after peripheral nerve injury (PNI) could represent a valid therapeutic strategy to prevent maladaptive synaptic plasticity in central nervous system (CNS). Inhibition of matrix metalloproteinases (MMPs) and maintaining a neurotrophic support could represent two approaches to prevent or reduce the maladaptive plastic changes in the ventral horn of spinal cord following PNI. The purpose of our study was to analyze changes in the ventral horn produced by gliopathy determined by the suffering of motor neurons following spared nerve injury (SNI) of the sciatic nerve and how the intrathecal (i.t.) administration of GM6001 (a MMPs inhibitor) or the NGF mimetic peptide BB14 modulate these events....
By proteolytic cleavage, matrix metalloproteinases (MMPs) not only remodel the extracellular matrix ...
<p><b>Copyright information:</b></p><p>Taken from "Matrix metalloproteinases and their inhibitors in...
Peripheral nerve injury results in persistent motor deficits, even after the nerve regenerates and m...
Modulation of extracellular matrix (ECM) remodeling after peripheral nerve injury (PNI) could repres...
The extracellular matrix (ECM) of the central nervous system (CNS) plays a pivotal role in the patho...
Reactive astrocytes and activated microglia are the key players in several pathophysiologic modifica...
Peptidomimetics hold a great promise as therapeutic agents for neurodegenerative disorders. We previ...
The maladaptive response of the central nervous system (CNS) following nerve injury is primarily lin...
The functionality and stability of the central nervous system (CNS) pabulum, called neural extracell...
Summary: This review will focus on matrix metalloproteinases (MMPs) and their inhibitors in the cont...
AbstractBackgroundAlthough the mammalian central nervous system contains numerous matrix metalloprot...
Dysfunctions of the neuronal-glial crosstalk and/or impaired signaling of neurotrophic factors repre...
<p><b>Copyright information:</b></p><p>Taken from "Matrix metalloproteinases and their inhibitors in...
<p><b>Copyright information:</b></p><p>Taken from "Matrix metalloproteinases and their inhibitors in...
<p>Scale bar = 200 μm. (A-F): Representative microphotographs showing avulsion-induced astrocyte rea...
By proteolytic cleavage, matrix metalloproteinases (MMPs) not only remodel the extracellular matrix ...
<p><b>Copyright information:</b></p><p>Taken from "Matrix metalloproteinases and their inhibitors in...
Peripheral nerve injury results in persistent motor deficits, even after the nerve regenerates and m...
Modulation of extracellular matrix (ECM) remodeling after peripheral nerve injury (PNI) could repres...
The extracellular matrix (ECM) of the central nervous system (CNS) plays a pivotal role in the patho...
Reactive astrocytes and activated microglia are the key players in several pathophysiologic modifica...
Peptidomimetics hold a great promise as therapeutic agents for neurodegenerative disorders. We previ...
The maladaptive response of the central nervous system (CNS) following nerve injury is primarily lin...
The functionality and stability of the central nervous system (CNS) pabulum, called neural extracell...
Summary: This review will focus on matrix metalloproteinases (MMPs) and their inhibitors in the cont...
AbstractBackgroundAlthough the mammalian central nervous system contains numerous matrix metalloprot...
Dysfunctions of the neuronal-glial crosstalk and/or impaired signaling of neurotrophic factors repre...
<p><b>Copyright information:</b></p><p>Taken from "Matrix metalloproteinases and their inhibitors in...
<p><b>Copyright information:</b></p><p>Taken from "Matrix metalloproteinases and their inhibitors in...
<p>Scale bar = 200 μm. (A-F): Representative microphotographs showing avulsion-induced astrocyte rea...
By proteolytic cleavage, matrix metalloproteinases (MMPs) not only remodel the extracellular matrix ...
<p><b>Copyright information:</b></p><p>Taken from "Matrix metalloproteinases and their inhibitors in...
Peripheral nerve injury results in persistent motor deficits, even after the nerve regenerates and m...