PURPOSE OF REVIEW: Muscle wasting and impaired muscle oxidative metabolism are common extrapulmonary features of chronic respiratory failure (CRF) that significantly increase disease burden. This review aims to address the question whether hypoxia, an obvious consequence of this disease, actually plays a causal role in these muscle impairments. RECENT FINDINGS: In experimental models, a causal role for hypoxia in muscle atrophy and metabolic impairments has clearly been shown. Although the hypoxia-inducible factors and nuclear factor kappa B are putative mediators of these hypoxia-induced alterations, their true involvement remains to be proven. Molecular signatures of disrupted regulation of muscle mass and oxidative metabolism observed in...
Chronic hypoxia leads to muscle atrophy. The molecular mechanisms responsible for this phenomenon ar...
International audienceSkeletal muscle is a metabolically active tissue and the major body protein re...
Skeletal muscle undergoes metabolic remodelling in response to environmental hypoxia, yet aspects of...
International audiencePURPOSE OF REVIEW: Muscle wasting and impaired muscle oxidative metabolism are...
PURPOSE OF REVIEW: Muscle wasting and impaired muscle oxidative metabolism are common extrapulmonary...
Hypoxia is the result of a decrease in arterial O2 availability and maybe induced by pathological or...
UNLABELLED: Hypoxia-induced muscle wasting has been observed in several environmental and pathologic...
Background : Skeletal muscle atrophy is an important feature of chronic obstructive pulmonary diseas...
Hypoxia is a state of lowered oxygen tension that can be created by environmental or pathological co...
Chronic hypoxia leads to muscle atrophy. The molecular mechanisms responsible for this phenomenon ar...
The striated muscles of breathing play a critical role in respiratory homeostasis governing blood ox...
Hypoxia is the result of a decrease in arterial O2 availability and maybe induced by pathological or...
Many people suffering from chronic obstructive pulmonary disease (COPD) have not only low oxygen lev...
Introduction: Hypoxia is a state of reduced O2 tension in tissue, including skeletal muscle. It elic...
Muscular dystrophies (MDs) are a group of inherited degenerative muscle disorders characterized by a...
Chronic hypoxia leads to muscle atrophy. The molecular mechanisms responsible for this phenomenon ar...
International audienceSkeletal muscle is a metabolically active tissue and the major body protein re...
Skeletal muscle undergoes metabolic remodelling in response to environmental hypoxia, yet aspects of...
International audiencePURPOSE OF REVIEW: Muscle wasting and impaired muscle oxidative metabolism are...
PURPOSE OF REVIEW: Muscle wasting and impaired muscle oxidative metabolism are common extrapulmonary...
Hypoxia is the result of a decrease in arterial O2 availability and maybe induced by pathological or...
UNLABELLED: Hypoxia-induced muscle wasting has been observed in several environmental and pathologic...
Background : Skeletal muscle atrophy is an important feature of chronic obstructive pulmonary diseas...
Hypoxia is a state of lowered oxygen tension that can be created by environmental or pathological co...
Chronic hypoxia leads to muscle atrophy. The molecular mechanisms responsible for this phenomenon ar...
The striated muscles of breathing play a critical role in respiratory homeostasis governing blood ox...
Hypoxia is the result of a decrease in arterial O2 availability and maybe induced by pathological or...
Many people suffering from chronic obstructive pulmonary disease (COPD) have not only low oxygen lev...
Introduction: Hypoxia is a state of reduced O2 tension in tissue, including skeletal muscle. It elic...
Muscular dystrophies (MDs) are a group of inherited degenerative muscle disorders characterized by a...
Chronic hypoxia leads to muscle atrophy. The molecular mechanisms responsible for this phenomenon ar...
International audienceSkeletal muscle is a metabolically active tissue and the major body protein re...
Skeletal muscle undergoes metabolic remodelling in response to environmental hypoxia, yet aspects of...