BACKGROUND: Human RNA polymerase III (pol III) transcription is regulated by several factors, including the tumor suppressors P53 and Rb, and the proto-oncogene c-Myc. In yeast, which lacks these proteins, a central regulator of pol III transcription, called Maf1, has been described. Maf1 is required for repression of pol III transcription in response to several signal transduction pathways and is broadly conserved in eukaryotes. METHODOLOGY/PRINCIPAL FINDINGS: We show that human endogenous Maf1 can be co-immunoprecipitated with pol III and associates in vitro with two pol III subunits, the largest subunit RPC1 and the alpha-like subunit RPAC2. Maf1 represses pol III transcription in vitro and in vivo and is required for maximal pol III rep...
RNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under stress condition...
The synthesis of transfer RNA (tRNA) is directed by RNA polymerase III (Pol III) specialized in high...
mTORC1 is a central regulator of growth in response to nutrient availability, but few direct targets...
Human RNA polymerase III (pol III) transcription is regulated by several factors, including the tumo...
Human RNA polymerase III (pol III) transcription is regulated by several factors, including the tumo...
BACKGROUND: Human RNA polymerase III (pol III) transcription is regulated by several factors, includ...
RNA polymerase III (RNA pol III) transcribes many of the small structural RNA molecules involved in ...
Maf1 was the first protein discovered to regulate polymerase III RNA in yeast and because it is evol...
RNA polymerase III (Pol III) is tightly controlled in response to environmental cues, yet a genomic-...
RNA polymerase III (Pol III) is tightly controlled in response to environmental cues, yet a genomic-...
mTORC1 is a central regulator of growth in response to nutrient availability, but few direct targets...
RNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under stress condition...
SummaryRNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under stress co...
Yeast and mammalian MAF1 are both regulated by the TOR (target of rapamycin) pathway. However, the e...
<p><b>Copyright information:</b></p><p>Taken from "Human Maf1 negatively regulates RNA Polymerase II...
RNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under stress condition...
The synthesis of transfer RNA (tRNA) is directed by RNA polymerase III (Pol III) specialized in high...
mTORC1 is a central regulator of growth in response to nutrient availability, but few direct targets...
Human RNA polymerase III (pol III) transcription is regulated by several factors, including the tumo...
Human RNA polymerase III (pol III) transcription is regulated by several factors, including the tumo...
BACKGROUND: Human RNA polymerase III (pol III) transcription is regulated by several factors, includ...
RNA polymerase III (RNA pol III) transcribes many of the small structural RNA molecules involved in ...
Maf1 was the first protein discovered to regulate polymerase III RNA in yeast and because it is evol...
RNA polymerase III (Pol III) is tightly controlled in response to environmental cues, yet a genomic-...
RNA polymerase III (Pol III) is tightly controlled in response to environmental cues, yet a genomic-...
mTORC1 is a central regulator of growth in response to nutrient availability, but few direct targets...
RNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under stress condition...
SummaryRNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under stress co...
Yeast and mammalian MAF1 are both regulated by the TOR (target of rapamycin) pathway. However, the e...
<p><b>Copyright information:</b></p><p>Taken from "Human Maf1 negatively regulates RNA Polymerase II...
RNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under stress condition...
The synthesis of transfer RNA (tRNA) is directed by RNA polymerase III (Pol III) specialized in high...
mTORC1 is a central regulator of growth in response to nutrient availability, but few direct targets...