Recent studies showed that kidney-specific inactivation of Kif3a produces kidney cysts and renal failure, suggesting that kinesin-mediated intracellular transportation is important for the establishement and maintenance of renal epithelial cell polarity and normal nephron functions. Kif5b, one of the most conserved kinesin heavy chain, is the mouse homologue of the human ubiquitous Kinesin Heavy Chain (uKHC). In order to elucidate the role of Kif5b in kidney development and function, it is essential to establish its expression profile within the organ. Therefore, in this study, we examined the expression pattern of Kif5b in mouse kidney. Kidneys from embryonic (E) 12.5-, 16.5-dpc (days post coitus) mouse fetuses, from postnatal (P) day 0, 1...
The development of the mammalian kidney is well conserved from mouse to man. Despite considerable te...
<p>Na<sup>+</sup>/K<sup>+</sup>-ATPase was basolaterally localized in renal epithelial cells of cont...
<div><p>The primary cilium is required during early embryo patterning, epithelial tubulogenesis, and...
<p>(A-D) Immunolocalization of Kif5b protein in the fetal mouse kidney at embryonic days (E) 12.5, 1...
<p>(A, B) Kif5b was widely distributed inside renal tubular epithelial cells of newborn mice. (C-H) ...
<p>Kif5b was expressed in TAL (THP-positive tubules) and DCT (NCC-positive tubules), but not in PT (...
Kif26b, a member of the kinesin superfamily proteins (KIFs), is essential for kidney development. Ki...
<p>Co-immunostaining of Kif5b (red) and apical markers LTL, THP, NCC and DBA (green) in kidney secti...
The mammalian kidney develops through two major processes: nephrogenesis and renal branching morphog...
The primary cilium is required during early embryo patterning, epithelial tubulogenesis, and growth ...
<p>Kif5b was expressed in TAL (THP-positive tubules) and DCT (NCC-positive tubules), but not in PT (...
Renal tubular reabsorption is important for extra-cellular fluid homeostasis and much of this occurs...
The development of the mammalian kidney is well conserved from mouse to man. Despite considerable te...
Kinesins are motor proteins responsible for the anterograde transport on microtubules. Kinesin-1 is ...
The development of the mammalian kidney is well conserved from mouse to man. Despite considerable te...
The development of the mammalian kidney is well conserved from mouse to man. Despite considerable te...
<p>Na<sup>+</sup>/K<sup>+</sup>-ATPase was basolaterally localized in renal epithelial cells of cont...
<div><p>The primary cilium is required during early embryo patterning, epithelial tubulogenesis, and...
<p>(A-D) Immunolocalization of Kif5b protein in the fetal mouse kidney at embryonic days (E) 12.5, 1...
<p>(A, B) Kif5b was widely distributed inside renal tubular epithelial cells of newborn mice. (C-H) ...
<p>Kif5b was expressed in TAL (THP-positive tubules) and DCT (NCC-positive tubules), but not in PT (...
Kif26b, a member of the kinesin superfamily proteins (KIFs), is essential for kidney development. Ki...
<p>Co-immunostaining of Kif5b (red) and apical markers LTL, THP, NCC and DBA (green) in kidney secti...
The mammalian kidney develops through two major processes: nephrogenesis and renal branching morphog...
The primary cilium is required during early embryo patterning, epithelial tubulogenesis, and growth ...
<p>Kif5b was expressed in TAL (THP-positive tubules) and DCT (NCC-positive tubules), but not in PT (...
Renal tubular reabsorption is important for extra-cellular fluid homeostasis and much of this occurs...
The development of the mammalian kidney is well conserved from mouse to man. Despite considerable te...
Kinesins are motor proteins responsible for the anterograde transport on microtubules. Kinesin-1 is ...
The development of the mammalian kidney is well conserved from mouse to man. Despite considerable te...
The development of the mammalian kidney is well conserved from mouse to man. Despite considerable te...
<p>Na<sup>+</sup>/K<sup>+</sup>-ATPase was basolaterally localized in renal epithelial cells of cont...
<div><p>The primary cilium is required during early embryo patterning, epithelial tubulogenesis, and...