Assessment of Acute Oral and Dermal Toxicity of 2 Ethyl-Carbamates with Activity against Rhipicephalus microplus in Rats
- María Guadalupe Prado-Ochoa
- Ricardo Alfonso Gutiérrez-Amezquita
- Víctor Hugo Abrego-Reyes
- Ana María Velázquez-Sánchez
- Marco Antonio Muñoz-Guzmán
- Patricia Ramírez-Noguera
- Enrique Angeles
- Fernando Alba-Hurtado
DOIAbstract
The acute oral and dermal toxicity of two new ethyl-carbamates (ethyl-4-bromophenyl-carbamate and ethyl-4-chlorophenyl-carbamate) with ixodicide activity was determined in rats. The oral LD50 of each carbamate was 300 to 2000 mg/kg, and the dermal LD50 of each carbamate was >5000 mg/kg. Clinically, the surviving rats that had received oral doses of each carbamate showed decreased weight gain (P<0.05) and had slight nervous system manifestations. These clinical signs were evident from the 300 mg/kg dose and were reversible, whereas the 2000 mg/kg dose caused severe damage and either caused their death or was motive for euthanasia. At necropsy, these rats had dilated stomachs and cecums with diffuse congestion, as well as moderate congestion ...
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