Targeting viral vectors to certain tissues in vivo has been a major challenge in gene therapy. Cell type-directed vector capsids can be selected from random peptide libraries displayed on viral capsids in vitro but so far this system could not easily be translated to in vivo applications. Using a novel, PCR-based amplification protocol for peptide libraries displayed on adeno-associated virus (AAV), we selected vectors for optimized transduction of primary tumor cells in vitro. However, these vectors were not suitable for transduction of the same target cells under in vivo conditions. We therefore performed selections of AAV peptide libraries in vivo in living animals after intravenous administration using tumor and lung tissue as prototype...
Augmenting cancer treatment by protein and gene delivery continues to gain momentum based on success...
The gene therapy field is currently limited by the lack of vehicles that permit efficient gene deliv...
Augmenting cancer treatment by protein and gene delivery continues to gain momentum based on success...
Targeting viral vectors to certain tissues in vivo has been a major challenge in gene therapy. Cell ...
The targeting of gene transfer at the cell-entry level is one of the most attractive challenges in v...
The targeting of gene transfer at the cell-entry level is one of the most attractive challenges in v...
Selection of viral vectors by screening viral display peptide libraries is an auspicious approach to...
Efficiency and specificity of viral vectors are vital issues in gene therapy. Insertion of peptide l...
Virus-mediated gene delivery is restricted by the infectivity profile of the chosen vector. Targetin...
Adenovirus serotype 5 remains one of the most promising vectors for delivering genetic material to c...
Due to the fundamental progress in elucidating the molecular mechanisms of human diseases and the ar...
Clinical application of viral vectors is often hampered by the lack of selectivity of viral particle...
Gene therapy offers a promise for treating inherited muscle disorders. The advantages of recombinant...
Gene therapy offers a promise for treating inherited muscle disorders. The advantages of recombinant...
Successful gene therapy for breast and ovarian cancer will likely require that anti-cancer genes be ...
Augmenting cancer treatment by protein and gene delivery continues to gain momentum based on success...
The gene therapy field is currently limited by the lack of vehicles that permit efficient gene deliv...
Augmenting cancer treatment by protein and gene delivery continues to gain momentum based on success...
Targeting viral vectors to certain tissues in vivo has been a major challenge in gene therapy. Cell ...
The targeting of gene transfer at the cell-entry level is one of the most attractive challenges in v...
The targeting of gene transfer at the cell-entry level is one of the most attractive challenges in v...
Selection of viral vectors by screening viral display peptide libraries is an auspicious approach to...
Efficiency and specificity of viral vectors are vital issues in gene therapy. Insertion of peptide l...
Virus-mediated gene delivery is restricted by the infectivity profile of the chosen vector. Targetin...
Adenovirus serotype 5 remains one of the most promising vectors for delivering genetic material to c...
Due to the fundamental progress in elucidating the molecular mechanisms of human diseases and the ar...
Clinical application of viral vectors is often hampered by the lack of selectivity of viral particle...
Gene therapy offers a promise for treating inherited muscle disorders. The advantages of recombinant...
Gene therapy offers a promise for treating inherited muscle disorders. The advantages of recombinant...
Successful gene therapy for breast and ovarian cancer will likely require that anti-cancer genes be ...
Augmenting cancer treatment by protein and gene delivery continues to gain momentum based on success...
The gene therapy field is currently limited by the lack of vehicles that permit efficient gene deliv...
Augmenting cancer treatment by protein and gene delivery continues to gain momentum based on success...