Prostate, pancreatic, and head and neck carcinomas have a high propensity to invade nerves. Surgical resection is a treatment modality for these patients, but it may incur significant deficits. The development of an imaging method able to detect neural invasion (NI) by cancer cells may guide surgical resection and facilitate preservation of normal nerves. We describe an imaging method for the detection of NI using a herpes simplex virus, NV1066, carrying tyrosine kinase and enhanced green fluorescent protein (eGFP). Infection of pancreatic (MiaPaCa2), prostate (PC3 and DU145), and adenoid cystic carcinoma (ACC3) cell lines with NV1066 induced a high expression of eGFP in vitro. An in vivo murine model of NI was established by implanting tum...
Tumor infiltrating stem cells have been suggested as a vehicle for the delivery of a suicide gene to...
Perineural invasion (PNI) by cancer cells is an ominous clinical event that is associated with incre...
For clinical application of stem cell–based therapies, noninvasive detection of applied stem cells i...
AbstractProstate, pancreatic, and head and neck carcinomas have a high propensity to invade nerves. ...
Surgical management of head and neck cancer requires a careful balance between complete resection of...
Pancreatic cancer (PC) is a fatal malignancy in the human abdominal cavity that prefers to invade th...
IMAGING NERVES: Tetnus Toxin Offers Promise for Neurography INBRIEF: Fight-or-Flight Hormones Linked...
ObjectivesLymph node status is the most important prognostic factor determining recurrence and survi...
Despite intensive research efforts and therapeutic advances over the last few decades, the pediatric...
Despite intensive research efforts and therapeutic advances over the last few decades, the pediatric...
A diagnosis of perineural invasion (PNI), defined as cancer within or surrounding at least 33% of th...
Radiolabelled ganciclovir analogues have shown promise as imaging agents to detect herpes simplex vi...
Tumor infiltrating stem cells have been suggested as a vehicle for the delivery of a suicide gene to...
Pancreatic ductal adenocarcinoma (PDAC) cells have an exceptional ability to invade nerves through p...
MICCAI endorsed event A distinct feature of malignant tumors compared to normal tissue or benign tu...
Tumor infiltrating stem cells have been suggested as a vehicle for the delivery of a suicide gene to...
Perineural invasion (PNI) by cancer cells is an ominous clinical event that is associated with incre...
For clinical application of stem cell–based therapies, noninvasive detection of applied stem cells i...
AbstractProstate, pancreatic, and head and neck carcinomas have a high propensity to invade nerves. ...
Surgical management of head and neck cancer requires a careful balance between complete resection of...
Pancreatic cancer (PC) is a fatal malignancy in the human abdominal cavity that prefers to invade th...
IMAGING NERVES: Tetnus Toxin Offers Promise for Neurography INBRIEF: Fight-or-Flight Hormones Linked...
ObjectivesLymph node status is the most important prognostic factor determining recurrence and survi...
Despite intensive research efforts and therapeutic advances over the last few decades, the pediatric...
Despite intensive research efforts and therapeutic advances over the last few decades, the pediatric...
A diagnosis of perineural invasion (PNI), defined as cancer within or surrounding at least 33% of th...
Radiolabelled ganciclovir analogues have shown promise as imaging agents to detect herpes simplex vi...
Tumor infiltrating stem cells have been suggested as a vehicle for the delivery of a suicide gene to...
Pancreatic ductal adenocarcinoma (PDAC) cells have an exceptional ability to invade nerves through p...
MICCAI endorsed event A distinct feature of malignant tumors compared to normal tissue or benign tu...
Tumor infiltrating stem cells have been suggested as a vehicle for the delivery of a suicide gene to...
Perineural invasion (PNI) by cancer cells is an ominous clinical event that is associated with incre...
For clinical application of stem cell–based therapies, noninvasive detection of applied stem cells i...