BACKGROUND:Insulin-like growth factor binding protein-3 (IGFBP-3) is a multifunctional molecule which is closely related to cell growth, apoptosis, angiogenesis, metabolism and senescence. It combines with insulin-like growth factor-I (IGF-I) to form a complex (IGF-I/IGFBP-3) that can treat growth hormone insensitivity syndrome (GHIS) and reduce insulin requirement in patients with diabetes. IGFBP-3 alone has been shown to have anti-proliferation effect on numerous cancer cells. METHODOLOGY/PRINCIPAL FINDINGS:We reported here an expression method to produce functional recombinant human IGFBP-3 (rhIGFBP-3) in transgenic rice grains. Protein sorting sequences, signal peptide and endoplasmic reticulum retention tetrapeptide (KDEL) were include...
The insulin-like growth factor (IGF) pathway promotes breast cancer and disease progression through ...
Insulin-like growth factors (IGFs) are known to have potent antiapoptotic activity. The antiestrogen...
2018-11-14Since proinsulin-transferrin (ProINS-Tf) fusion protein was designed and expressed from th...
Background: Insulin-like growth factor binding protein-3 (IGFBP-3) is a multifunctional molecule whi...
Insulin-like growth factor I (IGF-I) is a polypeptide protein hormone similar to insulin. It plays a...
The insulin gene family, comprised of insulin, relaxin, and insulin-like growth factors 1 and 2 (IGF...
<p>(A) Equal amount (3.125 mg seed) of WT, SB and SBK total seed protein extracts were added to the ...
<p>Different concentration of seed proteins (ranged from 1.042 to 15.625 mg) from WT and transgenic ...
Insulin-like growth factor binding protein-3 (IGFBP-3) has antiproliferative effects in many cell ty...
Insulin-like growth factor binding protein (IGFBP)-3 has been shown to potently inhibit proliferatio...
BACKGROUND: Insulin-like growth factors (IGF-I and IGF-II) signal via the type 1 IGF receptor (IGF-1...
BACKGROUND: Insulin-like growth factors (IGF-I and IGF-II) signal via the type 1 IGF receptor (IGF-1...
Insulin-like growth factor-binding protein-3 (IGFBP-3) is a multifunctional protein that induces apo...
This study explores the relationship between anti-proliferative signaling by transforming growth fac...
nsulin-like growth factor binding protein-3 (IGFBP-3) has both IGF-dependent and -independent effect...
The insulin-like growth factor (IGF) pathway promotes breast cancer and disease progression through ...
Insulin-like growth factors (IGFs) are known to have potent antiapoptotic activity. The antiestrogen...
2018-11-14Since proinsulin-transferrin (ProINS-Tf) fusion protein was designed and expressed from th...
Background: Insulin-like growth factor binding protein-3 (IGFBP-3) is a multifunctional molecule whi...
Insulin-like growth factor I (IGF-I) is a polypeptide protein hormone similar to insulin. It plays a...
The insulin gene family, comprised of insulin, relaxin, and insulin-like growth factors 1 and 2 (IGF...
<p>(A) Equal amount (3.125 mg seed) of WT, SB and SBK total seed protein extracts were added to the ...
<p>Different concentration of seed proteins (ranged from 1.042 to 15.625 mg) from WT and transgenic ...
Insulin-like growth factor binding protein-3 (IGFBP-3) has antiproliferative effects in many cell ty...
Insulin-like growth factor binding protein (IGFBP)-3 has been shown to potently inhibit proliferatio...
BACKGROUND: Insulin-like growth factors (IGF-I and IGF-II) signal via the type 1 IGF receptor (IGF-1...
BACKGROUND: Insulin-like growth factors (IGF-I and IGF-II) signal via the type 1 IGF receptor (IGF-1...
Insulin-like growth factor-binding protein-3 (IGFBP-3) is a multifunctional protein that induces apo...
This study explores the relationship between anti-proliferative signaling by transforming growth fac...
nsulin-like growth factor binding protein-3 (IGFBP-3) has both IGF-dependent and -independent effect...
The insulin-like growth factor (IGF) pathway promotes breast cancer and disease progression through ...
Insulin-like growth factors (IGFs) are known to have potent antiapoptotic activity. The antiestrogen...
2018-11-14Since proinsulin-transferrin (ProINS-Tf) fusion protein was designed and expressed from th...