Wnt proteins comprise a large family of secreted ligands implicated in a wide variety of biological roles. WntD has previously been shown to inhibit the nuclear accumulation of Dorsal/NF-κB protein during embryonic dorsal/ventral patterning and the adult innate immune response, independent of the well-studied Armadillo/β-catenin pathway. In this paper, we present a novel phenotype for WntD mutant embryos, suggesting that this gene is involved in migration of primordial germ cells (PGC) to the embryonic gonad. Additionally, we describe a genetic suppressor/enhancer screen aimed at identifying genes required for WntD signal transduction, based on the previous observation that maternal overexpression of WntD results in lethally dorsalized embr...
AbstractThe highly conserved Wnt family of growth factors is essential for generating embryonic patt...
AbstractWnt genes encode secreted growth factors that exhibit potent effects on both embryonic and p...
AbstractRobust animal development, tissue homeostasis, and stem cell renewal requires precise contro...
Wnt/Wingless (Wg) signaling is one of the major molecular pathways regulating formation of the anter...
An early event in Drosophila melanogaster gonad formation requires germ cells to move from the devel...
AbstractPrimordial germ cells (PGCs) undergo proliferation, invasion, guided migration, and aggregat...
Drosophila Wingless (Wg) belongs to the Wnt family of secreted glycoproteins that play essential rol...
Germline stem cell (GSC) self-renewal and differentiation into gametes is regulated by both intrinsi...
Organogenesis is a complex process, requiring cells to find their correct location and associate wit...
Quantitative information about the range of influence of extracellular signaling molecules is critic...
Evolutionarily conserved cell signaling pathways regulate diverse and indispensable processes during...
AbstractThe passage of an individual's genome to future generations is essential for the maintenance...
AbstractIn Drosophila embryos, germ cells and somatic cells are formed separately. A recent analysis...
Activation of NFkappaB plays a pivotal role in many cellular processes such as inflammation, prolife...
Wnt ligands and their downstream pathway components coordinate many developmental and cellular proce...
AbstractThe highly conserved Wnt family of growth factors is essential for generating embryonic patt...
AbstractWnt genes encode secreted growth factors that exhibit potent effects on both embryonic and p...
AbstractRobust animal development, tissue homeostasis, and stem cell renewal requires precise contro...
Wnt/Wingless (Wg) signaling is one of the major molecular pathways regulating formation of the anter...
An early event in Drosophila melanogaster gonad formation requires germ cells to move from the devel...
AbstractPrimordial germ cells (PGCs) undergo proliferation, invasion, guided migration, and aggregat...
Drosophila Wingless (Wg) belongs to the Wnt family of secreted glycoproteins that play essential rol...
Germline stem cell (GSC) self-renewal and differentiation into gametes is regulated by both intrinsi...
Organogenesis is a complex process, requiring cells to find their correct location and associate wit...
Quantitative information about the range of influence of extracellular signaling molecules is critic...
Evolutionarily conserved cell signaling pathways regulate diverse and indispensable processes during...
AbstractThe passage of an individual's genome to future generations is essential for the maintenance...
AbstractIn Drosophila embryos, germ cells and somatic cells are formed separately. A recent analysis...
Activation of NFkappaB plays a pivotal role in many cellular processes such as inflammation, prolife...
Wnt ligands and their downstream pathway components coordinate many developmental and cellular proce...
AbstractThe highly conserved Wnt family of growth factors is essential for generating embryonic patt...
AbstractWnt genes encode secreted growth factors that exhibit potent effects on both embryonic and p...
AbstractRobust animal development, tissue homeostasis, and stem cell renewal requires precise contro...