The Wnt/β-catenin or canonical Wnt signaling pathway plays fundamental roles in early development and in maintaining adult tissue homeostasis. R-spondin 3 (Rspo3) is a secreted protein that has been implicated in activating the Wnt/β-catenin signaling in amphibians and mammals. Here we report that zebrafish Rspo3 plays a negative role in regulating the zygotic Wnt/β-catenin signaling. Zebrafish Rspo3 has a unique domain structure. It contains a third furin-like (FU3) domain. This FU3 is present in other four ray-finned fish species studied but not in elephant shark. In zebrafish, rspo3 mRNA is maternally deposited and has a ubiquitous expression in early embryonic stages. After 12 hpf, its expression becomes tissue-specific. Forced expressi...
AbstractCaveolin-1 (Cav-1) is the principal component of plasma membrane caveolae that negatively re...
F-spondin, an extracellular matrix protein, is an important player in embryonic morphogenesis and CN...
Craniofacial development requires signals from epithelia to pattern skeletogenic neural crest (NC) c...
The Wnt/b-catenin or canonical Wnt signaling pathway plays fundamental roles in early development an...
Cynoglossus semilaevis is an important economic fish species and has long been cultivated in China. ...
AbstractWe have carried out a small pool expression screen for modulators of the Wnt/β-catenin pathw...
AbstractR-spondin (Rspo) encodes a multi-domain protein that modulates the Wnt-signaling pathway. Tw...
<p>(<b>A</b>) Rspo3 inhibited Wnt/β-catenin reporter activities. One-cell stage embryos were injecte...
Abstract The Wnt pathway activates target genes by controlling the β-catenin-T-cell factor (TCF) tra...
<p>(<b>A, B</b>) Effect of <i>rspo3</i> knockdown (A) and overexpression (B) on the expression of <i...
FOXO genes are involved in many aspects of development and vascular homeostasis by regulating cell a...
SummaryThe R-Spondin (Rspo) family of secreted Wnt modulators is involved in development and disease...
AbstractAlthough Wnt signaling plays an important role in body patterning during early vertebrate em...
AbstractMouse R-spondin3 (Rspo3) is a member of the R-spondin protein family, which is characterized...
β-catenin is a central effector of the Wnt pathway and one of the players in Ca+-dependent cell-cell...
AbstractCaveolin-1 (Cav-1) is the principal component of plasma membrane caveolae that negatively re...
F-spondin, an extracellular matrix protein, is an important player in embryonic morphogenesis and CN...
Craniofacial development requires signals from epithelia to pattern skeletogenic neural crest (NC) c...
The Wnt/b-catenin or canonical Wnt signaling pathway plays fundamental roles in early development an...
Cynoglossus semilaevis is an important economic fish species and has long been cultivated in China. ...
AbstractWe have carried out a small pool expression screen for modulators of the Wnt/β-catenin pathw...
AbstractR-spondin (Rspo) encodes a multi-domain protein that modulates the Wnt-signaling pathway. Tw...
<p>(<b>A</b>) Rspo3 inhibited Wnt/β-catenin reporter activities. One-cell stage embryos were injecte...
Abstract The Wnt pathway activates target genes by controlling the β-catenin-T-cell factor (TCF) tra...
<p>(<b>A, B</b>) Effect of <i>rspo3</i> knockdown (A) and overexpression (B) on the expression of <i...
FOXO genes are involved in many aspects of development and vascular homeostasis by regulating cell a...
SummaryThe R-Spondin (Rspo) family of secreted Wnt modulators is involved in development and disease...
AbstractAlthough Wnt signaling plays an important role in body patterning during early vertebrate em...
AbstractMouse R-spondin3 (Rspo3) is a member of the R-spondin protein family, which is characterized...
β-catenin is a central effector of the Wnt pathway and one of the players in Ca+-dependent cell-cell...
AbstractCaveolin-1 (Cav-1) is the principal component of plasma membrane caveolae that negatively re...
F-spondin, an extracellular matrix protein, is an important player in embryonic morphogenesis and CN...
Craniofacial development requires signals from epithelia to pattern skeletogenic neural crest (NC) c...