Study on pathogenesis of schistosomal liver fibrosis

The important pathological feature induced by schistosomiasis is liver fibrosis. Schistosome eggs release soluble egg antigen to form egg granuloma, which stimulates host inflammation, induces extracellular matrix deposition, and finally causes liver fibrosis. This process is tightly associated with hepatic stellate cells, T cells, and other cytokines. Deep understanding of cellular and molecular mechanisms of schistosomiasis-induced liver fibrosis will help to identify targets for drug development and clinical treatment, and bring new hope to patients with schistosomiasis-induced liver fibrosis