Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes

Ayami Kajiwara
Ayana Kita
Junji Saruwatari
Hiroko Miyazaki
Yuki Kawata
Kazunori Morita
Kentaro Oniki
Akira Yoshida
Hideaki Jinnouchi
Kazuko Nakagawa

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Publication date

January 2016

DOI

10.1155/2016/4626382

Publisher

Hindawi Limited

ISSN

2314-6745

Journal

issn:2314-6753

Citation count (estimate)

Abstract

Aims. We aimed to investigate the sex differences in the renal function decline among patients with type 2 diabetic mellitus (T2DM), focusing on the differences in the risk factors at early stage of renal dysfunction. Methods. A clinic-based retrospective longitudinal study (follow-up duration: 8.1±1.4 years) was conducted to assess the sex differences in the annual estimated glomerular filtration rate (eGFR) change in 344 (247 male and 97 female) Japanese T2DM patients. The sex differences in the risk factors of annual eGFR decline were subjected to linear regression analyses. Results. The mean annual eGFR change was -3.5±2.7%/year in females and -2.0±2.2%/year in males (P<0.001). Baseline retinopathy and proteinuria were significantly ass...