DNA methylation is fundamental for the stability and activity of genomes. Drosophila melanogaster and vertebrates establish a global DNA methylation pattern of their genome during early embryogenesis. Large-scale analyses of DNA methylation patterns have uncovered revealed that DNA methylation patterns are dynamic rather than static and change in a gene-specific fashion during development and in diseased cells. However, the factors and mechanisms involved in dynamic, postembryonic DNA methylation remain unclear. Methylation of lysine 9 in histone H3 (H3-K9) by members of the Su(var)3-9 family of histone methyltransferases (HMTs) triggers embryonic DNA methylation in Arthropods and Chordates. Here, we demonstrate that Drosophila SETDB1 (dSET...
AbstractBackground: The heterochromatin of many eukaryotes is marked by both DNA methylation and his...
AbstractLysine methylation of histones is associated with both transcriptionally active chromatin an...
Cytosine methylation in the genome of Drosophila melanogaster has been elusive and controversial: It...
DNA methylation is fundamental for the stability and activity of genomes. Drosophila melanogaster an...
Histone H3 lysine 9 ( H3K9) methylation is associated with gene repression and heterochromatin forma...
Germline-stem cells (GSCs) produce gametes and are thus true "immortal stem cells". In Drosophila ov...
Methyl-DNA binding proteins play an important role in epigenetic gene regulation. The Drosophila gen...
Histone post-translational modifications play an important role in regulating chromatin structure an...
SummaryDNA N6-methyladenine (6mA) modification is commonly found in microbial genomes and plays impo...
[[abstract]]C methylation at genomic CpG dinucleotides has been implicated in the regulation of a nu...
SummaryHistone-tail modifications play a fundamental role in the processes that establish chromatin ...
Setdb1/Eset, a histone H3-lysine 9 (H3K9)-specific methyltransferase, interacts with various transcr...
AbstractBackground: Covalent modifications of histone N-terminal tails play fundamental roles in reg...
The histone lysine demethylase 4 (Kdm4/Jmjd2/Jhdm3) family is highly conserved across species and re...
In Drosophila, two chromosomes require special mechanisms to balance their transcriptional output to...
AbstractBackground: The heterochromatin of many eukaryotes is marked by both DNA methylation and his...
AbstractLysine methylation of histones is associated with both transcriptionally active chromatin an...
Cytosine methylation in the genome of Drosophila melanogaster has been elusive and controversial: It...
DNA methylation is fundamental for the stability and activity of genomes. Drosophila melanogaster an...
Histone H3 lysine 9 ( H3K9) methylation is associated with gene repression and heterochromatin forma...
Germline-stem cells (GSCs) produce gametes and are thus true "immortal stem cells". In Drosophila ov...
Methyl-DNA binding proteins play an important role in epigenetic gene regulation. The Drosophila gen...
Histone post-translational modifications play an important role in regulating chromatin structure an...
SummaryDNA N6-methyladenine (6mA) modification is commonly found in microbial genomes and plays impo...
[[abstract]]C methylation at genomic CpG dinucleotides has been implicated in the regulation of a nu...
SummaryHistone-tail modifications play a fundamental role in the processes that establish chromatin ...
Setdb1/Eset, a histone H3-lysine 9 (H3K9)-specific methyltransferase, interacts with various transcr...
AbstractBackground: Covalent modifications of histone N-terminal tails play fundamental roles in reg...
The histone lysine demethylase 4 (Kdm4/Jmjd2/Jhdm3) family is highly conserved across species and re...
In Drosophila, two chromosomes require special mechanisms to balance their transcriptional output to...
AbstractBackground: The heterochromatin of many eukaryotes is marked by both DNA methylation and his...
AbstractLysine methylation of histones is associated with both transcriptionally active chromatin an...
Cytosine methylation in the genome of Drosophila melanogaster has been elusive and controversial: It...