Psoriasis Hastalarında Biyolojik Tedavinin Sistemik İnflamatuvar Belirteçler ve Plateletcrit Üzerine Etkisi

Objectives: Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of keratinocytes and inflammatory cell infiltration. Circulating inflammatory markers are increased in patients with psoriasis. The objective of this study is to assess neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), RDW to platelet ratio (RPR) and plateletcrit (PCT) as inflammatory markers in patients with psoriasis whom treated with biological agents. Methods: Forty-two patients with psoriasis vulgaris whom treated with biological agents were evaluated retrospectively. Information about demographics, clinics, and complete blood count of the patients before initiation and after 3 months of biological treatment were collected. Results: Erythrocyte sedimantation rate (ESR), C-reactive protein (CRP), neutrophil, platelet, PCT, RDW, NLR, and PLR were significantly reduced in the posttreatment results compared with the pretreatment results (p<0,05). Also, there were no statistically significant difference in terms of MPV, PDW, LMR, and RPR results (p>0,05). Conclusion: NLR, PLR and PCT may be used as a marker to evaluate biological agent treatment efficacy on psoriasis vulgaris patients