BACKGROUND: Screening tests for Trisomy 21 (T21), also known as Down syndrome, are routinely performed for the majority of pregnant women. However, current tests rely on either evaluating non-specific markers, which lead to false negative and false positive results, or on invasive tests, which while highly accurate, are expensive and carry a risk of fetal loss. We outline a novel, rapid, highly sensitive, and targeted approach to non-invasively detect fetal T21 using maternal plasma DNA. METHODS AND FINDINGS: Highly heterozygous tandem Single Nucleotide Polymorphism (SNP) sequences on chromosome 21 were analyzed using High-Fidelity PCR and Cycling Temperature Capillary Electrophoresis (CTCE). This approach was used to blindly analyze plasma...
NIPT for fetal aneuploidy by digital PCR has been hampered by the large number of PCR reactions need...
NIPT for fetal aneuploidy by digital PCR has been hampered by the large number of PCR reactions need...
BACKGROUND: Noninvasive prenatal diagnosis of tri-somy 21 (T21) has recently been shown to be achiev...
Screening tests for Trisomy 21 (T21), also known as Down syndrome, are routinely performed for the m...
Screening tests for Trisomy 21 (T21), also known as Down syndrome, are routinely performed for the m...
Background Screening tests for Trisomy 21 (T21), also known as Down syndrome, are routinely perfo...
Background: Screening tests for Trisomy 21 (T21), also known as Down syndrome, are routinely perform...
BACKGROUND: Plasma DNA obtained from a pregnant woman contains a mixture of maternal and fetal DNA. ...
Plasma DNA obtained from a pregnant woman contains a mixture of maternal and fetal DNA. The fetal DN...
<div><h3>Background</h3><p>Plasma DNA obtained from a pregnant woman contains a mixture of maternal ...
Introduction: Down syndrome is a predominant genetic disease with an incident rate of one in every 7...
Abstract Non-invasive prenatal tests for the detection of fetal aneuploidies are predominantly based...
Objectives To validate the clinical efficacy and practical feasibility of massively parallel materna...
Cytogenetic analysis still remains the gold standard method for prenatal diagnosis of trisomy 21 (Do...
Background Prenatal diagnosis of chromosomal abnormality requires cytogenetic analysis of amniotic f...
NIPT for fetal aneuploidy by digital PCR has been hampered by the large number of PCR reactions need...
NIPT for fetal aneuploidy by digital PCR has been hampered by the large number of PCR reactions need...
BACKGROUND: Noninvasive prenatal diagnosis of tri-somy 21 (T21) has recently been shown to be achiev...
Screening tests for Trisomy 21 (T21), also known as Down syndrome, are routinely performed for the m...
Screening tests for Trisomy 21 (T21), also known as Down syndrome, are routinely performed for the m...
Background Screening tests for Trisomy 21 (T21), also known as Down syndrome, are routinely perfo...
Background: Screening tests for Trisomy 21 (T21), also known as Down syndrome, are routinely perform...
BACKGROUND: Plasma DNA obtained from a pregnant woman contains a mixture of maternal and fetal DNA. ...
Plasma DNA obtained from a pregnant woman contains a mixture of maternal and fetal DNA. The fetal DN...
<div><h3>Background</h3><p>Plasma DNA obtained from a pregnant woman contains a mixture of maternal ...
Introduction: Down syndrome is a predominant genetic disease with an incident rate of one in every 7...
Abstract Non-invasive prenatal tests for the detection of fetal aneuploidies are predominantly based...
Objectives To validate the clinical efficacy and practical feasibility of massively parallel materna...
Cytogenetic analysis still remains the gold standard method for prenatal diagnosis of trisomy 21 (Do...
Background Prenatal diagnosis of chromosomal abnormality requires cytogenetic analysis of amniotic f...
NIPT for fetal aneuploidy by digital PCR has been hampered by the large number of PCR reactions need...
NIPT for fetal aneuploidy by digital PCR has been hampered by the large number of PCR reactions need...
BACKGROUND: Noninvasive prenatal diagnosis of tri-somy 21 (T21) has recently been shown to be achiev...