Emerging evidence suggests that connexin mediated gap junctional intercellular communication contributes to many aspects of bone biology including bone development, maintenance of bone homeostasis and responsiveness of bone cells to diverse extracellular signals. Deletion of connexin 43, the predominant gap junction protein in bone, is embryonic lethal making it challenging to examine the role of connexin 43 in bone in vivo. However, transgenic murine models in which only osteocytes and osteoblasts are deficient in connexin 43, and which are fully viable, have recently been developed. Unfortunately, the bone phenotype of different connexin 43 deficient models has been variable. To address this issue, we used an osteocalcin driven Cre-lox sy...
Regulation of bone homeostasis depends on the concerted actions of bone-forming osteoblasts and bone...
AbstractGap junctions play a critical role in the coordinated function and activity of nearly all of...
Cell and animal studies conducted onboard the International Space Station and formerly on Shuttle fl...
AbstractGap junctional intercellular communication (GJIC) mediated by connexins, in particular conne...
Gap junctions are formed from ubiquitously expressed proteins called connexins that allow the transf...
AbstractThe role of gap junctions, particularly that of connexin43 (Cx43), has become an area of inc...
Gap junctional intercellular communication has been demonstrated in bone cells and may contribute to...
Osteoporosis and sarcopenia (termed “Osteosarcopenia”), the twin-aging diseases, are major contribut...
Gap junctions (GJs) formed by connexins (Cxs) play an important role in the intercellular communicat...
The gap junction protein, connexin43 (Cx43) is involved in mechanotransduction in bone. Recent studi...
Connexin 43 (Cx43) mediates osteocyte communication with other cells and with the extracellular mili...
International audienceElectron micrographs revealed the presence of gap junctions in osteoblastic ce...
Connexin 43 (Cx43) is the most abundant gap junction protein in bone and is required for osteoblasti...
Connexin 43 (Cx43) mediates osteocyte communication with other cells and with the extracellular mili...
Background: Connexin proteins are essential for cell differentiation, function, and survival. Result...
Regulation of bone homeostasis depends on the concerted actions of bone-forming osteoblasts and bone...
AbstractGap junctions play a critical role in the coordinated function and activity of nearly all of...
Cell and animal studies conducted onboard the International Space Station and formerly on Shuttle fl...
AbstractGap junctional intercellular communication (GJIC) mediated by connexins, in particular conne...
Gap junctions are formed from ubiquitously expressed proteins called connexins that allow the transf...
AbstractThe role of gap junctions, particularly that of connexin43 (Cx43), has become an area of inc...
Gap junctional intercellular communication has been demonstrated in bone cells and may contribute to...
Osteoporosis and sarcopenia (termed “Osteosarcopenia”), the twin-aging diseases, are major contribut...
Gap junctions (GJs) formed by connexins (Cxs) play an important role in the intercellular communicat...
The gap junction protein, connexin43 (Cx43) is involved in mechanotransduction in bone. Recent studi...
Connexin 43 (Cx43) mediates osteocyte communication with other cells and with the extracellular mili...
International audienceElectron micrographs revealed the presence of gap junctions in osteoblastic ce...
Connexin 43 (Cx43) is the most abundant gap junction protein in bone and is required for osteoblasti...
Connexin 43 (Cx43) mediates osteocyte communication with other cells and with the extracellular mili...
Background: Connexin proteins are essential for cell differentiation, function, and survival. Result...
Regulation of bone homeostasis depends on the concerted actions of bone-forming osteoblasts and bone...
AbstractGap junctions play a critical role in the coordinated function and activity of nearly all of...
Cell and animal studies conducted onboard the International Space Station and formerly on Shuttle fl...