Colorectal carcinoma (CRC) is the most common cancer of the gastrointestinal tract with frequently dysregulated intracellular signaling pathways, including p53 signaling. The mainstay of chemotherapy treatment of CRC is 5-fluorouracil (5FU) and oxaliplatin. The two anticancer drugs mediate their therapeutic effect via DNA damage-triggered signaling. The small molecule reactivating p53 and inducing tumor apoptosis (RITA) is described as an activator of wild-type and reactivator of mutant p53 function, resulting in elevated levels of p53 protein, cell growth arrest, and cell death. Additionally, it has been shown that RITA can induce DNA damage signaling. It is expected that the therapeutic benefits of 5FU and oxaliplatin can be increased by ...
International audienceBackground: The aim of this study was to evaluate the efficacy of the p53-reac...
International audienceBackground: The aim of this study was to evaluate the efficacy of the p53-reac...
International audienceBackground: The aim of this study was to evaluate the efficacy of the p53-reac...
Colorectal carcinoma (CRC) is the most common cancer of the gastrointestinal tract with frequently d...
Colorectal carcinoma (CRC) is the most common cancer of the gastrointestinal tract with frequently d...
The p53 tumor suppressor plays an important role in cell fate decisions upon diverse stress conditi...
SummaryTargeting “oncogene addiction” is a promising strategy for anticancer therapy. We report a po...
SummaryTargeting “oncogene addiction” is a promising strategy for anticancer therapy. We report a po...
The low frequency of p53 alterations e.g., mutations/deletions (∼10%) in multiple myeloma (MM) makes...
The first tumour-suppressor gene to be identified was p53. Reactivation of p53 and induction of tumo...
The first tumour-suppressor gene to be identified was p53. Reactivation of p53 and induction of tumo...
<div><p>The low frequency of p53 alterations e.g., mutations/deletions (∼10%) in multiple myeloma (M...
Inactivation of the tumor suppressor p53 is essential for the development and maintenance of cancer...
Background and Objective: The use of low-molecular-weight, nonpeptidic molecules that degrade the in...
The tumor suppressor p53 is a transcription factor that is crucial for protecting cells from cancer ...
International audienceBackground: The aim of this study was to evaluate the efficacy of the p53-reac...
International audienceBackground: The aim of this study was to evaluate the efficacy of the p53-reac...
International audienceBackground: The aim of this study was to evaluate the efficacy of the p53-reac...
Colorectal carcinoma (CRC) is the most common cancer of the gastrointestinal tract with frequently d...
Colorectal carcinoma (CRC) is the most common cancer of the gastrointestinal tract with frequently d...
The p53 tumor suppressor plays an important role in cell fate decisions upon diverse stress conditi...
SummaryTargeting “oncogene addiction” is a promising strategy for anticancer therapy. We report a po...
SummaryTargeting “oncogene addiction” is a promising strategy for anticancer therapy. We report a po...
The low frequency of p53 alterations e.g., mutations/deletions (∼10%) in multiple myeloma (MM) makes...
The first tumour-suppressor gene to be identified was p53. Reactivation of p53 and induction of tumo...
The first tumour-suppressor gene to be identified was p53. Reactivation of p53 and induction of tumo...
<div><p>The low frequency of p53 alterations e.g., mutations/deletions (∼10%) in multiple myeloma (M...
Inactivation of the tumor suppressor p53 is essential for the development and maintenance of cancer...
Background and Objective: The use of low-molecular-weight, nonpeptidic molecules that degrade the in...
The tumor suppressor p53 is a transcription factor that is crucial for protecting cells from cancer ...
International audienceBackground: The aim of this study was to evaluate the efficacy of the p53-reac...
International audienceBackground: The aim of this study was to evaluate the efficacy of the p53-reac...
International audienceBackground: The aim of this study was to evaluate the efficacy of the p53-reac...