The increased expression of the Disintegrin and Metalloprotease ADAM12 has been associated with human cancers, however its role remain unclear. We have previously reported that ADAM12 expression is induced by the transforming growth factor, TGF-β and promotes TGF-β-dependent signaling through interaction with the type II receptor of TGF-β. Here we explore the implication of ADAM12 in TGF-β-mediated epithelial to mesenchymal transition (EMT), a key process in cancer progression. We show that ADAM12 expression is correlated with EMT markers in human breast cancer cell lines and biopsies. Using a non-malignant breast epithelial cell line (MCF10A), we demonstrate that TGF-β-induced EMT increases expression of the membrane-anchored ADAM12L long ...
Citation: Duhachek-Muggy, S., Qi, Y., Wise, R., Alyahya, L., Li, H., Hodge, J., & Zolkiewska, A. (20...
The ADAM ( a disintegrin and metalloprotease) family consists of multidomain cell-surface proteins t...
The transmembrane glycoprotein basigin, a member of the immunoglobulin superfamily, stimulates matri...
<div><p>The increased expression of the Disintegrin and Metalloprotease ADAM12 has been associated w...
ADAMs (a disintegrin and metalloprotease) can influence multiple cellular processes involved in norm...
Communication between tumoral cells and the microenvironnement plays an essential role in the develo...
Doctor of PhilosophyDepartment of BiochemistryAnna ZolkiewskaADAMs (a disintegrin and metalloproteas...
Les échanges entre les cellules tumorales et le microenvironnement jouent un rôle essentiel dans le ...
As in developmental and regenerative processes, cell survival is of fundamental importance in cancer...
International audienceTransforming growth factor-beta (TGF-beta) regulates a wide variety of biologi...
Expression of ADAM12 is low in most normal tissues but is markedly increased in numerous human cance...
International audienceThe epithelial mesenchymal transition (EMT) is a key process for cancer cell i...
Abstract ADAMTS12 is a gene widely expressed in human tissues. We studied the expression level of AD...
AbstractADAM12, a disintegrin and metalloprotease, has been demonstrated to be upregulated in human ...
<p>(A), MCF10A cells were stimulated with TGF-β (5ng/ml) for 24, 48 and 96 hours and control cells w...
Citation: Duhachek-Muggy, S., Qi, Y., Wise, R., Alyahya, L., Li, H., Hodge, J., & Zolkiewska, A. (20...
The ADAM ( a disintegrin and metalloprotease) family consists of multidomain cell-surface proteins t...
The transmembrane glycoprotein basigin, a member of the immunoglobulin superfamily, stimulates matri...
<div><p>The increased expression of the Disintegrin and Metalloprotease ADAM12 has been associated w...
ADAMs (a disintegrin and metalloprotease) can influence multiple cellular processes involved in norm...
Communication between tumoral cells and the microenvironnement plays an essential role in the develo...
Doctor of PhilosophyDepartment of BiochemistryAnna ZolkiewskaADAMs (a disintegrin and metalloproteas...
Les échanges entre les cellules tumorales et le microenvironnement jouent un rôle essentiel dans le ...
As in developmental and regenerative processes, cell survival is of fundamental importance in cancer...
International audienceTransforming growth factor-beta (TGF-beta) regulates a wide variety of biologi...
Expression of ADAM12 is low in most normal tissues but is markedly increased in numerous human cance...
International audienceThe epithelial mesenchymal transition (EMT) is a key process for cancer cell i...
Abstract ADAMTS12 is a gene widely expressed in human tissues. We studied the expression level of AD...
AbstractADAM12, a disintegrin and metalloprotease, has been demonstrated to be upregulated in human ...
<p>(A), MCF10A cells were stimulated with TGF-β (5ng/ml) for 24, 48 and 96 hours and control cells w...
Citation: Duhachek-Muggy, S., Qi, Y., Wise, R., Alyahya, L., Li, H., Hodge, J., & Zolkiewska, A. (20...
The ADAM ( a disintegrin and metalloprotease) family consists of multidomain cell-surface proteins t...
The transmembrane glycoprotein basigin, a member of the immunoglobulin superfamily, stimulates matri...