During vertebrate neurulation, cranial neural crest cells (CNCCs) undergo epithelial to mesenchymal transition (EMT), delaminate from the neural plate border, and migrate as separate streams into different cranial regions. There, they differentiate into distinct parts of the craniofacial skeleton. Canonical Wnt signaling has been shown to be essential for this process at different levels but the involved receptors remained unclear. Here we show that the frizzled co-receptor low-density-lipoprotein (LDL) receptor-related protein 5 (Lrp5) plays a crucial role in CNCC migration and morphogenesis of the cranial skeleton. Early during induction and migration of CNCCs, lrp5 is expressed ubiquitously but later gets restricted to CNCC derivatives i...
Directional migration of neural crest (NC) cells is essential for patterning the vertebrate em-bryo,...
During vertebrate development, trunk neural crest cells delaminate along the entire length of the do...
Neural crest (NC) cells migrate throughout vertebrate embryos to give rise to a huge variety of cell...
During vertebrate neurulation, cranial neural crest cells (CNCCs) undergo epithelial to mesenchymal ...
During vertebrate neurulation, cranial neural crest cells (CNCCs) undergo epithelial to mes-enchymal...
During craniofacial development, defective growth and fusion of the upper lip and/or palate can caus...
Craniofacial development requires signals from epithelia to pattern skeletogenic neural crest (NC) c...
Craniofacial development requires signals from epithelia to pattern skeletogenic neural crest (NC) c...
The canonical Wnt signaling pathway is critical for skeletal development and maintenance, but the pr...
Wnt signaling plays a vital role in many developmental processes. Wnt signaling has been implicated ...
The neural crest (NC) is a vertebrate-specific population of multipotent cells, often referred to as...
<p>(A) Lateral view of a 22 hour old embryo stained with the pan-neural crest cell marker <i>crestin...
The neural crest (NC) is an embryonic population of cells, which delaminate from the neural tube epi...
<div><p>Directional migration of neural crest (NC) cells is essential for patterning the vertebrate ...
Directional migration of neural crest (NC) cells is essential for patterning the vertebrate embryo, ...
Directional migration of neural crest (NC) cells is essential for patterning the vertebrate em-bryo,...
During vertebrate development, trunk neural crest cells delaminate along the entire length of the do...
Neural crest (NC) cells migrate throughout vertebrate embryos to give rise to a huge variety of cell...
During vertebrate neurulation, cranial neural crest cells (CNCCs) undergo epithelial to mesenchymal ...
During vertebrate neurulation, cranial neural crest cells (CNCCs) undergo epithelial to mes-enchymal...
During craniofacial development, defective growth and fusion of the upper lip and/or palate can caus...
Craniofacial development requires signals from epithelia to pattern skeletogenic neural crest (NC) c...
Craniofacial development requires signals from epithelia to pattern skeletogenic neural crest (NC) c...
The canonical Wnt signaling pathway is critical for skeletal development and maintenance, but the pr...
Wnt signaling plays a vital role in many developmental processes. Wnt signaling has been implicated ...
The neural crest (NC) is a vertebrate-specific population of multipotent cells, often referred to as...
<p>(A) Lateral view of a 22 hour old embryo stained with the pan-neural crest cell marker <i>crestin...
The neural crest (NC) is an embryonic population of cells, which delaminate from the neural tube epi...
<div><p>Directional migration of neural crest (NC) cells is essential for patterning the vertebrate ...
Directional migration of neural crest (NC) cells is essential for patterning the vertebrate embryo, ...
Directional migration of neural crest (NC) cells is essential for patterning the vertebrate em-bryo,...
During vertebrate development, trunk neural crest cells delaminate along the entire length of the do...
Neural crest (NC) cells migrate throughout vertebrate embryos to give rise to a huge variety of cell...