The large and rapidly increasing number of potentially pathological mutants in the type 1 ryanodine receptor (RyR1) prompts the need to characterize their effects on voltage-activated sarcoplasmic reticulum (SR) Ca(2+) release in skeletal muscle. Here we evaluated the function of the R4892W and G4896V RyR1 mutants, both associated with central core disease (CCD) in humans, in myotubes and in adult muscle fibers. For both mutants expressed in RyR1-null (dyspedic) myotubes, voltage-gated Ca(2+) release was absent following homotypic expression and only partially restored following heterotypic expression with wild-type (WT) RyR1. In muscle fibers from adult WT mice, both mutants were expressed in restricted regions of the fibers with a pattern...
1. Primary cultured myotubes were derived from satellite cells of the diaphragm obtained from both n...
The type 1 ryanodine receptor (RyR1) is expressed widely in the brain, with high levels in the cereb...
The type 1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel on the sarco...
The large and rapidly increasing number of potentially pathological mutants in the type 1 ryanodine ...
<div><p>The large and rapidly increasing number of potentially pathological mutants in the type 1 ry...
The type 1 isoform of the ryanodine receptor (RYR1) is the Ca 2+ release channel of the sarcoplasmic...
Abstract Physiological muscle contraction requires an intact ligand gating mechanism of the ryanodin...
Ryanodine receptor (RyR), a homotetrameric Ca2+ release channel, is one of the main actors in the ge...
Dysregulation of calcium signals due to defects of skeletal muscle sarcoplasmic reticulum calcium re...
Ryanodine receptors plays a crucial role in skeletal muscle excitation-contraction coupling by relea...
Skeletal muscle excitation-contraction coupling involves activation of homotetrameric ryanodine rece...
International audienceSkeletal muscle deficiency in the 3-phosphoinositide (PtdInsP) phosphatase myo...
The physiological properties and role of the type 3 ryanodine receptor (RyR3), a calcium release cha...
Les ions Ca2+ responsables de la contraction musculaire sont extrudés du réticulum sarcoplasmique (R...
Ryanodine receptors plays a crucial role in skeletal muscle excitation-contraction coupling by relea...
1. Primary cultured myotubes were derived from satellite cells of the diaphragm obtained from both n...
The type 1 ryanodine receptor (RyR1) is expressed widely in the brain, with high levels in the cereb...
The type 1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel on the sarco...
The large and rapidly increasing number of potentially pathological mutants in the type 1 ryanodine ...
<div><p>The large and rapidly increasing number of potentially pathological mutants in the type 1 ry...
The type 1 isoform of the ryanodine receptor (RYR1) is the Ca 2+ release channel of the sarcoplasmic...
Abstract Physiological muscle contraction requires an intact ligand gating mechanism of the ryanodin...
Ryanodine receptor (RyR), a homotetrameric Ca2+ release channel, is one of the main actors in the ge...
Dysregulation of calcium signals due to defects of skeletal muscle sarcoplasmic reticulum calcium re...
Ryanodine receptors plays a crucial role in skeletal muscle excitation-contraction coupling by relea...
Skeletal muscle excitation-contraction coupling involves activation of homotetrameric ryanodine rece...
International audienceSkeletal muscle deficiency in the 3-phosphoinositide (PtdInsP) phosphatase myo...
The physiological properties and role of the type 3 ryanodine receptor (RyR3), a calcium release cha...
Les ions Ca2+ responsables de la contraction musculaire sont extrudés du réticulum sarcoplasmique (R...
Ryanodine receptors plays a crucial role in skeletal muscle excitation-contraction coupling by relea...
1. Primary cultured myotubes were derived from satellite cells of the diaphragm obtained from both n...
The type 1 ryanodine receptor (RyR1) is expressed widely in the brain, with high levels in the cereb...
The type 1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel on the sarco...