Cystic fibrosis is associated with increased inflammatory responses to pathogen challenge. Here we revisited the role of IL-1β in lung pathology using the experimental F508del-CFTR murine model on C57BL/6 genetic background (Cftr(tm1eur) or d/d), on double deficient for d/d and type 1 interleukin-1 receptor (d/d X IL-1R1-/-), and antibody neutralization. At steady state, young adult d/d mice did not show any signs of spontaneous lung inflammation. However, IL-1R1 deficiency conferred partial protection to repeated P. aeruginosa endotoxins/LPS lung instillation in d/d mice, as 50% of d/d mice succumbed to inflammation, whereas all d/d x IL-1R1-/- double mutants survived with lower initial weight loss and less pulmonary collagen and mucus pro...
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inf...
Cystic fibrosis is associated with chronic Pseudomonas aeruginosa colonization and inflammation. The...
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inf...
textabstractCystic fibrosis is associated with increased inflammatory responses to pathogen challeng...
Cystic fibrosis is associated with increased inflammatory responses to pathogen challenge. Here we r...
Cystic fibrosis (CF) female patients have a worse prognosis compared to their male counterparts. CF ...
Lung disease is the major cause of mortality in cystic fibrosis patients. Lack of functional cystic ...
Several cystic fibrosis (CF) mouse models demonstrate an increased susceptibility to Pseudomonas aer...
Despite remarkable progress following the identification of the causing gene, the final outcome of c...
Cystic fibrosis (CF) is caused by homozygous mutations of the CF transmembrane conductance regulator...
<p>d/d and double KO d/d x IL-1R1<sup>−/−</sup> mice were treated intranasally with 80 µg of <i>P. a...
Inflammation and infection are major determinants of disease severity and consequently, the quality ...
textabstractCystic fibrosis (CF) is caused by homozygous mutations of the CF transmembrane conductan...
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inf...
Increasingly, cystic fibrosis (CF) is regarded as an inflammatory disorder where the response of the...
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inf...
Cystic fibrosis is associated with chronic Pseudomonas aeruginosa colonization and inflammation. The...
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inf...
textabstractCystic fibrosis is associated with increased inflammatory responses to pathogen challeng...
Cystic fibrosis is associated with increased inflammatory responses to pathogen challenge. Here we r...
Cystic fibrosis (CF) female patients have a worse prognosis compared to their male counterparts. CF ...
Lung disease is the major cause of mortality in cystic fibrosis patients. Lack of functional cystic ...
Several cystic fibrosis (CF) mouse models demonstrate an increased susceptibility to Pseudomonas aer...
Despite remarkable progress following the identification of the causing gene, the final outcome of c...
Cystic fibrosis (CF) is caused by homozygous mutations of the CF transmembrane conductance regulator...
<p>d/d and double KO d/d x IL-1R1<sup>−/−</sup> mice were treated intranasally with 80 µg of <i>P. a...
Inflammation and infection are major determinants of disease severity and consequently, the quality ...
textabstractCystic fibrosis (CF) is caused by homozygous mutations of the CF transmembrane conductan...
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inf...
Increasingly, cystic fibrosis (CF) is regarded as an inflammatory disorder where the response of the...
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inf...
Cystic fibrosis is associated with chronic Pseudomonas aeruginosa colonization and inflammation. The...
Dysregulated inflammasome activation contributes to respiratory infections and pathologic airway inf...