CD274, one of two co-stimulatory ligands for programmed death 1 and widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells and regulates inflammatory responses. However, changes in CD274 gene expression and the underlying molecular mechanism are poorly understood during inflammatory responses. Therefore, delineation of the complex mechanisms regulating CD274 expression is critical to understand this immunoregulatory system during inflammatory responses. The purpose of this study was to assess the molecular mechanisms regulating CD274 expression in an in vitro monocyte model of inflammatory response. Firstly, CD274 expression levels in human primary monocytes after lipopolysaccharide (LPS) treatment were observe...
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammaso...
Appropriate innate and adaptive immune responses are essential for protection and resolution against...
Signal transducer and activator of transcription-3 (STAT3) activation has been associated with suppr...
<div><p>CD274, one of two co-stimulatory ligands for programmed death 1 and widely expressed in the ...
<p>CD274 mRNA levels were determined by quantitative real-time PCR and are shown as fold changes in ...
AbstractThe nuclear factor κB (NF-κB) is thought to be crucially involved in the gene activation of ...
Since its discovery over 30 years ago the NF-ĸB family of transcription factors has gained the statu...
Monocytes and macrophages respond to bacterial components as a part of the innate immune response to...
<p>CD274 mRNA levels were determined by quantitative real-time PCR and are shown as fold changes in ...
Following major trauma, sepsis or surgery, some patients exhibit an impaired monocyte inflammatory r...
This study focuses on impaired monocyte function, which occurs in some patients after trauma, major ...
Monocytes play a central role in regulating inflammation in response to infection or injury, and dur...
CD40 is a costimulatory molecule linking innate and adaptive immune responses to bacterial stimuli, ...
Since its discovery over 30 years ago the NF-ĸB family of transcription factors has gained the statu...
Accumulation of lipid-laden macrophages is a hallmark of atherosclerosis. The relevance of the key t...
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammaso...
Appropriate innate and adaptive immune responses are essential for protection and resolution against...
Signal transducer and activator of transcription-3 (STAT3) activation has been associated with suppr...
<div><p>CD274, one of two co-stimulatory ligands for programmed death 1 and widely expressed in the ...
<p>CD274 mRNA levels were determined by quantitative real-time PCR and are shown as fold changes in ...
AbstractThe nuclear factor κB (NF-κB) is thought to be crucially involved in the gene activation of ...
Since its discovery over 30 years ago the NF-ĸB family of transcription factors has gained the statu...
Monocytes and macrophages respond to bacterial components as a part of the innate immune response to...
<p>CD274 mRNA levels were determined by quantitative real-time PCR and are shown as fold changes in ...
Following major trauma, sepsis or surgery, some patients exhibit an impaired monocyte inflammatory r...
This study focuses on impaired monocyte function, which occurs in some patients after trauma, major ...
Monocytes play a central role in regulating inflammation in response to infection or injury, and dur...
CD40 is a costimulatory molecule linking innate and adaptive immune responses to bacterial stimuli, ...
Since its discovery over 30 years ago the NF-ĸB family of transcription factors has gained the statu...
Accumulation of lipid-laden macrophages is a hallmark of atherosclerosis. The relevance of the key t...
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammaso...
Appropriate innate and adaptive immune responses are essential for protection and resolution against...
Signal transducer and activator of transcription-3 (STAT3) activation has been associated with suppr...