The Hippo pathway has recently been implicated in the regulation of organ size and stem cells in multiple tissues. The transcriptional cofactor yes-associated protein 1 (Yap1) is the most downstream effector of Hippo signaling and is functionally repressed by the upstream components of the pathway. Overexpression of YAP1 stimulates proliferation of stem and progenitor cells in many tissues, consistent with inhibition of Hippo signaling. To study the role of Hippo signaling in hematopoietic stem cells (HSCs), we created a transgenic model with inducible YAP1 expression exclusively within the hematopoietic system. Following 3 months induction, examination of blood and bone marrow in the induced mice revealed no changes in the distribution of ...
The Hippo pathway plays an important role in regulating tissue homeostasis, and its effectors, the t...
SummaryThe role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here w...
Yes-associated protein (YAP) is a Hippo signaling transcriptional coactivator that plays pivotal rol...
The Hippo pathway has recently been implicated in the regulation of organ size and stem cells in mul...
<div><p>The Hippo pathway has recently been implicated in the regulation of organ size and stem cell...
Hematopoiesis is the process of blood formation from a limited pool of hematopoietic stem cells (HSC...
ABSTRACT While several organs in mammals retain partial regenerative capability following tissue dam...
<p>(<b>A</b>) ES cell targeting vector containing tetracycline inducible promoter driving hYAP cDNA ...
The mechanism of body and organ size control is an unsolved puzzle. Recent Drosophila genetics studi...
The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here we repor...
The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue homeo...
The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and Lats) and down...
The Hippo pathway is a central regulator of organ size and tissue homeostasis. Hippo kinases and ada...
The HIPPO signaling pathway is highly conserved and affects organ development specifically through c...
The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here we repor...
The Hippo pathway plays an important role in regulating tissue homeostasis, and its effectors, the t...
SummaryThe role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here w...
Yes-associated protein (YAP) is a Hippo signaling transcriptional coactivator that plays pivotal rol...
The Hippo pathway has recently been implicated in the regulation of organ size and stem cells in mul...
<div><p>The Hippo pathway has recently been implicated in the regulation of organ size and stem cell...
Hematopoiesis is the process of blood formation from a limited pool of hematopoietic stem cells (HSC...
ABSTRACT While several organs in mammals retain partial regenerative capability following tissue dam...
<p>(<b>A</b>) ES cell targeting vector containing tetracycline inducible promoter driving hYAP cDNA ...
The mechanism of body and organ size control is an unsolved puzzle. Recent Drosophila genetics studi...
The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here we repor...
The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue homeo...
The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and Lats) and down...
The Hippo pathway is a central regulator of organ size and tissue homeostasis. Hippo kinases and ada...
The HIPPO signaling pathway is highly conserved and affects organ development specifically through c...
The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here we repor...
The Hippo pathway plays an important role in regulating tissue homeostasis, and its effectors, the t...
SummaryThe role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here w...
Yes-associated protein (YAP) is a Hippo signaling transcriptional coactivator that plays pivotal rol...