Serine and arginine rich splicing factor 2(SRSF2) belongs to the serine/arginine (SR)-rich family of proteins that regulate alternative splicing. Previous studies suggested that SRSF2 can contribute to carcinogenic processes. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer, highly aggressive and difficult to treat, mainly due to resistance to apoptosis. In this study we hypothesized that SRSF2 contributes to the regulation of apoptosis in ccRCC. Using tissue samples obtained from ccRCC patients, as well as independent validation on The Cancer Genome Atlas (TCGA) data, we demonstrate for the first time that expression of SRSF2 is decreased in ccRCC tumours when compared to non-tumorous control tissues. Fur...
Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splici...
Over the past decade, alternative splicing has been progressively recognized as a major mechanism re...
Up-regulation of the apoptosis-regulatory gene Mcl-1 (myeloid cell leukemia-1) occurs in different c...
Serine and arginine rich splicing factor 2(SRSF2) belongs to the serine/arginine (SR)-rich family of...
Splicing abnormalities frequently occur in cancer. A key role as splice site choice regulator is pla...
<div><p>Splicing abnormalities frequently occur in cancer. A key role as splice site choice regulato...
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cancer. One of ...
Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cancer. One of the processe...
Background: SFRS1 is a member of the splicing factor protein family. Through a specific sequence of ...
The splicing-factor oncoprotein SRSF1 (also known as SF2/ASF or ASF/SF2) is upregulated in breast ca...
Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression promotes transfo...
No potential conflicts of interests were disclosed. Serine/Arginine Splicing Factor 1 (SRSF1) is the...
International audienceThe transcription factor E2F1 belongs to the E2F family and plays a crucial ro...
BCL-2-Interacting Mediator of Cell Death (BIM) is a pro-apoptotic BH3-only protein that plays an imp...
Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splici...
Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splici...
Over the past decade, alternative splicing has been progressively recognized as a major mechanism re...
Up-regulation of the apoptosis-regulatory gene Mcl-1 (myeloid cell leukemia-1) occurs in different c...
Serine and arginine rich splicing factor 2(SRSF2) belongs to the serine/arginine (SR)-rich family of...
Splicing abnormalities frequently occur in cancer. A key role as splice site choice regulator is pla...
<div><p>Splicing abnormalities frequently occur in cancer. A key role as splice site choice regulato...
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cancer. One of ...
Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cancer. One of the processe...
Background: SFRS1 is a member of the splicing factor protein family. Through a specific sequence of ...
The splicing-factor oncoprotein SRSF1 (also known as SF2/ASF or ASF/SF2) is upregulated in breast ca...
Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression promotes transfo...
No potential conflicts of interests were disclosed. Serine/Arginine Splicing Factor 1 (SRSF1) is the...
International audienceThe transcription factor E2F1 belongs to the E2F family and plays a crucial ro...
BCL-2-Interacting Mediator of Cell Death (BIM) is a pro-apoptotic BH3-only protein that plays an imp...
Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splici...
Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splici...
Over the past decade, alternative splicing has been progressively recognized as a major mechanism re...
Up-regulation of the apoptosis-regulatory gene Mcl-1 (myeloid cell leukemia-1) occurs in different c...