Objectively Measured Physical Activity Is Associated with Brain Volumetric Measurements in Multiple Sclerosis

Background. Little is known about physical activity and its association with volumes of whole brain gray matter and white matter and deep gray matter structures in persons with multiple sclerosis (MS). Purpose. This study examined the association between levels of physical activity and brain volumetric measures from magnetic resonance imaging (MRI) in MS. Method. 39 persons with MS wore an accelerometer for a 7-day period and underwent a brain MRI. Normalized GM volume (NGMV), normalized WM volume (NWMV), and deep GM structures were calculated from 3D T1-weighted structural brain images. We conducted partial correlations (pr) controlling for demographic and clinical variables. Results. Moderate-to-vigorous physical activity (MVPA) was significantly associated with NGMV (pr=0.370, p<0.05), NWMV (pr=0.433, p<0.01), hippocampus (pr=0.499, p<0.01), thalamus (pr=0.380, p<0.05), caudate (pr=0.539, p<0.01), putamen (pr=0.369, p<0.05), and pallidum (pr=0.498, p