Zinc plays a critical role in many biological processes. However, it is toxic at high concentrations and its homeostasis is strictly regulated by metal-responsive transcription factor 1 (MTF-1) together with many other proteins to protect cells against metal toxicity and oxidative stresses. In this paper, we used high-resolution two-dimensional gel electrophoresis (2DE) to profile global changes of the whole soluble proteome in human lung adenocarcinoma (A549) cells in response to exogenous zinc treatment for 24 h. Eighteen differentially expressed proteins were identified by MALDI TOF/TOF and MASCOT search. In addition, we used Western blotting and RT-PCR to examine the time-dependent changes in expression of proteins regulated by MTF-1 in...
Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of man...
Worldwide, breast cancer is the most commonly diagnosed cancer among women and is the leading cause ...
The regulation of cellular zinc uptake is a key process in the overall mechanism governing mammalian...
<div><p>Zinc plays a critical role in many biological processes. However, it is toxic at high concen...
Zinc, an essential trace element, is involved in many important physiological processes. Cell respon...
<div><p>Zinc, an essential trace element, is involved in many important physiological processes. Cel...
A significant gap in the knowledge of zinc homeostasis exists for breast cancer cells. In this study...
Only a small number of genes are known direct targets of the zinc-responsive transcription factor MT...
The zinc homeostatic proteins Zn transporter 1 (ZNT1) and metallothionein (MT) function in dampening...
Zinc, an essential trace element, is involved in many important physiological processes. Cell respon...
PhD ThesisZinc is an essential trace element that plays a crucial role in catalytic, structural and ...
Zinc deficiency predisposes to a wide spectrum of chronic diseases. The human Zn proteome was predic...
Zinc has been suggested to play a role in carcinogenesis and tumor progression. Serum zinc levels of...
Zinc is involved in many physiological processes and is required as a catalytic cofactor for more th...
Zinc (Zn) is a crucial trace element involved in various cellular processes, including oxidative str...
Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of man...
Worldwide, breast cancer is the most commonly diagnosed cancer among women and is the leading cause ...
The regulation of cellular zinc uptake is a key process in the overall mechanism governing mammalian...
<div><p>Zinc plays a critical role in many biological processes. However, it is toxic at high concen...
Zinc, an essential trace element, is involved in many important physiological processes. Cell respon...
<div><p>Zinc, an essential trace element, is involved in many important physiological processes. Cel...
A significant gap in the knowledge of zinc homeostasis exists for breast cancer cells. In this study...
Only a small number of genes are known direct targets of the zinc-responsive transcription factor MT...
The zinc homeostatic proteins Zn transporter 1 (ZNT1) and metallothionein (MT) function in dampening...
Zinc, an essential trace element, is involved in many important physiological processes. Cell respon...
PhD ThesisZinc is an essential trace element that plays a crucial role in catalytic, structural and ...
Zinc deficiency predisposes to a wide spectrum of chronic diseases. The human Zn proteome was predic...
Zinc has been suggested to play a role in carcinogenesis and tumor progression. Serum zinc levels of...
Zinc is involved in many physiological processes and is required as a catalytic cofactor for more th...
Zinc (Zn) is a crucial trace element involved in various cellular processes, including oxidative str...
Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of man...
Worldwide, breast cancer is the most commonly diagnosed cancer among women and is the leading cause ...
The regulation of cellular zinc uptake is a key process in the overall mechanism governing mammalian...