Laparoskopik kolesistektomi sonrası postoperatif bulantı ve kusmanın önlenmesinde tropisetron ve palonosetron’un karşılaştırılması: Randomize, çift-kör çalışma

Objective: Postoperative nausea-vomiting (PONV) is one of the most common side effects after anesthesia. PONV extends the duration of hospital stay and recov­ery time of the patient after the surgery. In this study, we compared the effects of tropisetron on palonosetron on postoperative nausea and vomiting after laparoscopic cholecystectomy. Methods: After endotracheal intubation, Palonosetron Group (Group P) received iv 0.075 mg of palonosetron and Tropisetron Group (Group T) received iv 5 mg of tro­pisetron. VAS scores, antiemetic use and nausea-vomit­ing scores were recorded in 0-72 hours interval. Results: In the 0-24 and 48-72 hour intervals, there were no statistical difference between the groups with respect to nausea-vomiting scores, but, in the 24-48 hour interval, nausea-vomiting score was lower in Group P than Group T (p < 0.024) (Table 3). There was no statistical difference in all 72 hour intervals with respect to antiemetic use (p > 0.05). 72 hours total antiemetic use was statisticaly higher in Group T than Group P (p = 0.025) (Tablo 4). Conclusion: For PONV prophylaxis, palonosetron de­creased the PONV score and antiemetic need more than tropisetron in the first 72 hours