Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells : role of sphingosine kinase 1 and S1P lyase
- Berdyshev, Evgeny V
- Gorshkova, Irina
- Usatyuk, Peter
- Kalari, Satish
- Zhao, Yutong
- Pyne, Nigel J
- Pyne, Susan
- Sabbadini, Roger A
- Garcia, Joe G.N.
- Natarajan, Viswanathan
Publication date
January 2011
DOI Publisher
Public Library of Science (PLoS) Language
EnglishAbstract
Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade. As endothelial cells generate intracellular S1P, here we have investigated the role of sphingosine kinases (SphKs) and S1P lyase (S1PL), that regulate intracellular S1P accumulation, in HPAEC motility
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