Predictive factors of herpes zoster HIV-infected patients: another adverse effect of crack cocaine.

Mathieu Nacher
Celia Basurko
Antoine Adenis
Emilie Gaubert-Marechal
Emilie Mosnier
Sophie Edouard
Vincent Vantilcke
Sindou Sivapregassam
Benoit Tressières
André Cabié
Pierre Couppié

Open link

DOI

10.1371/journal.pone.0080187

Publisher

Public Library of Science (PLoS)

Journal

issn:1932-6203

Abstract

A retrospective cohort study was conducted on 1541 HIV-infected patients to determine variables associated with the incidence of herpes zoster. A single failure Cox model showed that herpes zoster incidence increased following the first 6 months of antiretroviral treatment adjusted hazard ratio (AHR)=5 (95%CI=2.6-9.2), P<0.001; in the >60 years age group AHR=2 (95%CI=1-4), P=0.04; in patients in the top CD8 quartile AHR=2.1 (95%CI=1.3-3.6), P<0.001; and in patients previously reported to use crack cocaine AHR=5.9, (95%CI=1.4-25), P=0.02. Herpes zoster incidence increased in patients with CD4 counts<500 per mm(3) and gradually declined since 1992-1996, with AHR=0.3 (95%CI=0.2-0.5), P<0.001 for the 1997-2002 period and AHR=0.24 (95%CI=0.14-0....