Whole-body and hepatic insulin resistance in obese children.
- Lorena del Rocío Ibarra-Reynoso
- Liudmila Pisarchyk
- Elva Leticia Pérez-Luque
- Ma Eugenia Garay-Sevilla
- Juan Manuel Malacara
DOIAbstract
Insulin resistance may be assessed as whole body or hepatic.To study factors associated with both types of insulin resistance.Cross-sectional study of 182 obese children. Somatometric measurements were registered, and the following three adiposity indexes were compared: BMI, waist-to-height ratio and visceral adiposity. Whole-body insulin resistance was evaluated using HOMA-IR, with 2.5 as the cut-off point. Hepatic insulin resistance was considered for IGFBP-1 level quartiles 1 to 3 (<6.67 ng/ml). We determined metabolite and hormone levels and performed a liver ultrasound.The majority, 73.1%, of obese children had whole-body insulin resistance and hepatic insulin resistance, while 7% did not have either type. HOMA-IR was negatively associ...
Add to ORKG