Characterization of wax granules containing paracetamol produced by a hot-melt spray system

Paracetamol of different particle-size ranges was incorporated into glyceryl monostearate (GMS) granules with the anticipation of producing a sustained-release oral delivery system from a hot-melt solid dispersion (Habib 2001). Subsequent characterization of these formulations indicated that drug release was dependent on particle size but not as anticipated by Noyes-Whitney (Martin et al 1983)