Cr (VI) is a known carcinogen that readily crosses the cellular membrane and is then reduced by intracellular reductants such as reduced glutathione (GSH) to Cr (III), forming various reactive intermediate compounds (Ding and Shi, 2002). The interaction of Cr (VI) and GSH is known to be one of the causes of DNA damage in vitro (Mazzer et al., 2007). This study investigates the occurrence of Cr (III)-GSH in freshly isolated rat hepatocytes incubated with Cr (VI), and the uptake of Cr (VI) and Cr (III)-GSH complex across rat liver cell nuclei. Cr (III)-GSH complex was synthesised by the method of Levina et al. (2003), and its formation confirmed by liquid chromatography-mass spectrometry (LC-MS)
Whilst chromium (Cr) compounds (particularly water soluble complexes) have long been recognised as c...
Background/Aims: In the present study, we explored reactive axygen species (ROS) production in mitoc...
Cr(VI) is a known human carcinogen. Although it has been investigated widely, the mechanism(s) of it...
Cr (VI) is a known carcinogen that readily crosses the cellular membrane and is then reduced by intr...
Chromium (VI) is an environmental and occupational carcinogen, and it is accepted that intracellular...
Chromium (VI) is an environmental and occupational carcinogen, and it is accepted that intracellular...
Chromium (VI) compounds have serious toxic and carcinogenic effects in humans. To exert toxicity and...
In patients with orthopaedic implants, metallic particles have been shown to be disseminated widely ...
The products of hexavalent chromium [Cr(VI)] reduction by glutathione (GSH) alone or in the presence...
High levels of metal ions, such as chromium and nickel, released from metallic total hip implants ha...
Isolated rat liver hepatocytes, previously depleted of gluta-thione (GSH) by treatment with diethylm...
AbstractThe interaction of mutagenic Cr(VI) with red blood cells has been studied by ESR spectroscop...
AbstractIncubation of Chinese hamster V-79 cells with either buthionine sulfoximine (BSO) or diethyl...
To exert cytotoxicity chromium VI (Cr(VI)) has to be reduced inside cells. This is achieved through ...
Chromium (VI) [Cr(VI)] and nitrosamines such as N-nitrosodimethylamine (NDMA) exist commonly in the ...
Whilst chromium (Cr) compounds (particularly water soluble complexes) have long been recognised as c...
Background/Aims: In the present study, we explored reactive axygen species (ROS) production in mitoc...
Cr(VI) is a known human carcinogen. Although it has been investigated widely, the mechanism(s) of it...
Cr (VI) is a known carcinogen that readily crosses the cellular membrane and is then reduced by intr...
Chromium (VI) is an environmental and occupational carcinogen, and it is accepted that intracellular...
Chromium (VI) is an environmental and occupational carcinogen, and it is accepted that intracellular...
Chromium (VI) compounds have serious toxic and carcinogenic effects in humans. To exert toxicity and...
In patients with orthopaedic implants, metallic particles have been shown to be disseminated widely ...
The products of hexavalent chromium [Cr(VI)] reduction by glutathione (GSH) alone or in the presence...
High levels of metal ions, such as chromium and nickel, released from metallic total hip implants ha...
Isolated rat liver hepatocytes, previously depleted of gluta-thione (GSH) by treatment with diethylm...
AbstractThe interaction of mutagenic Cr(VI) with red blood cells has been studied by ESR spectroscop...
AbstractIncubation of Chinese hamster V-79 cells with either buthionine sulfoximine (BSO) or diethyl...
To exert cytotoxicity chromium VI (Cr(VI)) has to be reduced inside cells. This is achieved through ...
Chromium (VI) [Cr(VI)] and nitrosamines such as N-nitrosodimethylamine (NDMA) exist commonly in the ...
Whilst chromium (Cr) compounds (particularly water soluble complexes) have long been recognised as c...
Background/Aims: In the present study, we explored reactive axygen species (ROS) production in mitoc...
Cr(VI) is a known human carcinogen. Although it has been investigated widely, the mechanism(s) of it...