The aim of this study was to investigate the mechanism of action of the preservative sodium chlorite (NaClO2), and the relationship with intracellular glutathione depletion. A detailed comparison of the dose responses of two cultured ocular epithelial cell types and four species of microorganism was carried out, and comparisons were also made with the quaternary ammonium compound benzalkonium chloride (BAK), and the oxidant hydrogen peroxide (H2O2). The viability of mammalian and microbial cells was assessed in the same way, by the measurement of intracellular ATP using a bioluminescence method. Intracellular total glutathione was measured by reaction with 5,5'-dithiobis-2-nitrobenzoic acid in a glutathione reductase-dependent recycling ass...
The ciliary epithelium (CE), the tissue responsible for aqueous humor (AH) production, is the outer ...
Purpose: Reports on cytotoxic effects of rigid gas-permeable lens multipurpose solutions, which rema...
Oxidative damage to lens epithelial cells plays an important role in the development of age-related ...
The aim of this study was to investigate the mechanism of action of the preservative sodium chlorite...
In this study the interaction of the preservative sodium chlorite with unsaturated lipids and glutat...
International audiencePurpose: Benzalkonium chloride (BAK), the most commonly used preservative in e...
We investigated the effects of instilling 13 commonly used preservatives on the murine cornea in viv...
Benzalkonium chloride (BAC) is currently the most commonly used antimicrobial preservative in ophtha...
Contact lens cases contaminated with Pseudomonas aeruginosa are a major risk factor in ocular infect...
This review examines the role of chlorine dioxide (ClO2) on inorganic compounds and cell biomolecule...
Objective To investigate the short-term impact on human conjunctival goblet cell (GC) survival and m...
A number of surfactants, including representatives of the cationic, anionic, nonionic, and amphoteri...
Preservatives are a major component of the ophthalmic preparations in multi-dose bottles. The purpos...
International audiencePurpose: Using an established three-dimensional (3D) toxicological model based...
Benzalkonium chloride (BAK) is a cationic detergent with a very slow turnover. Because of its strong...
The ciliary epithelium (CE), the tissue responsible for aqueous humor (AH) production, is the outer ...
Purpose: Reports on cytotoxic effects of rigid gas-permeable lens multipurpose solutions, which rema...
Oxidative damage to lens epithelial cells plays an important role in the development of age-related ...
The aim of this study was to investigate the mechanism of action of the preservative sodium chlorite...
In this study the interaction of the preservative sodium chlorite with unsaturated lipids and glutat...
International audiencePurpose: Benzalkonium chloride (BAK), the most commonly used preservative in e...
We investigated the effects of instilling 13 commonly used preservatives on the murine cornea in viv...
Benzalkonium chloride (BAC) is currently the most commonly used antimicrobial preservative in ophtha...
Contact lens cases contaminated with Pseudomonas aeruginosa are a major risk factor in ocular infect...
This review examines the role of chlorine dioxide (ClO2) on inorganic compounds and cell biomolecule...
Objective To investigate the short-term impact on human conjunctival goblet cell (GC) survival and m...
A number of surfactants, including representatives of the cationic, anionic, nonionic, and amphoteri...
Preservatives are a major component of the ophthalmic preparations in multi-dose bottles. The purpos...
International audiencePurpose: Using an established three-dimensional (3D) toxicological model based...
Benzalkonium chloride (BAK) is a cationic detergent with a very slow turnover. Because of its strong...
The ciliary epithelium (CE), the tissue responsible for aqueous humor (AH) production, is the outer ...
Purpose: Reports on cytotoxic effects of rigid gas-permeable lens multipurpose solutions, which rema...
Oxidative damage to lens epithelial cells plays an important role in the development of age-related ...