The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a cell death reaction termed heterokaryon incompatibility. This reaction is observed at the point of contact between two genetically distinct strains when one harbors a HET-s prion (in the form of amyloid aggregates) and the other expresses a soluble HET-S protein (96% identical to HET-s). How the HET-s prion interaction with HET-S brings about cell death remains unknown; however, it was recently shown that this interaction leads to a relocalization of HET-S from the cytoplasm to the cell periphery and that this change is associated with cell death. Here, we present detailed insights into this mechanism in which a non-toxic HET-s prion converts a soluble...
International audienceThe het-s locus is one of nine known het (heterokaryon incompatibility) loci o...
In the fungus Podospora anserina, the [Het-s] prion induces programmed cell death by activating the ...
AbstractThe prion-forming domain of the fungal prion protein HET-s, HET-s(218-289), is known from so...
The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a cell death...
Abstract: Prions are self-templating protein structures that can be transferred from organism to org...
<p>(1) In the fusion cell, HET-S (in blue with a red TM segment) encounters the β-solenoid structure...
Prions are kind of like Batman—they have a bad reputation, but they can also serve a number of good ...
AbstractMany studies have pointed out the interaction between amyloids and membranes, and their pote...
<p>(A) TEM image of freeze-fractured liposomes treated with HET-S at 30°C show that many liposomes c...
The HET-s protein of Podospora anserina is a fungal prion. This protein behaves as an infectious cyt...
International audienceThe folding and interactions of amyloid proteins are at the heart of the debat...
is involved in a cell death process associated with non-self recognition. The prion forming domain ...
Two alleles of the het-s/S locus occur naturally in the filamentous fungus Podospora anserina, het-s...
International audienceThe [Het-s] infectious element of the filamentous fungus Podospora anserina is...
<p>When two <i>P. anserina</i> mycelia fuse to form a heterokaryon, the Het-s/Het-S heterokaryon inc...
International audienceThe het-s locus is one of nine known het (heterokaryon incompatibility) loci o...
In the fungus Podospora anserina, the [Het-s] prion induces programmed cell death by activating the ...
AbstractThe prion-forming domain of the fungal prion protein HET-s, HET-s(218-289), is known from so...
The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a cell death...
Abstract: Prions are self-templating protein structures that can be transferred from organism to org...
<p>(1) In the fusion cell, HET-S (in blue with a red TM segment) encounters the β-solenoid structure...
Prions are kind of like Batman—they have a bad reputation, but they can also serve a number of good ...
AbstractMany studies have pointed out the interaction between amyloids and membranes, and their pote...
<p>(A) TEM image of freeze-fractured liposomes treated with HET-S at 30°C show that many liposomes c...
The HET-s protein of Podospora anserina is a fungal prion. This protein behaves as an infectious cyt...
International audienceThe folding and interactions of amyloid proteins are at the heart of the debat...
is involved in a cell death process associated with non-self recognition. The prion forming domain ...
Two alleles of the het-s/S locus occur naturally in the filamentous fungus Podospora anserina, het-s...
International audienceThe [Het-s] infectious element of the filamentous fungus Podospora anserina is...
<p>When two <i>P. anserina</i> mycelia fuse to form a heterokaryon, the Het-s/Het-S heterokaryon inc...
International audienceThe het-s locus is one of nine known het (heterokaryon incompatibility) loci o...
In the fungus Podospora anserina, the [Het-s] prion induces programmed cell death by activating the ...
AbstractThe prion-forming domain of the fungal prion protein HET-s, HET-s(218-289), is known from so...