Analysis on macular choroidal thickness of patients with myopic choroidal neovascularization

AIM: To examine choroidal thickness and its relationship with axial length and spherical equivalent by spectral domain optical coherence tomography(SD-OCT)in patients with myopic choroidal neovascularization(mCNV). <p>METHODS: We prospectively recruited 30 cases of mCNV in Beijing Anzhen Hospital from October 2010 to December 2014. SD-OCT was used to measure choroidal thickness subfoveally and at 1.5mm superiorly, inferiorly, nasally and temporally(SFCT, SCT_1.5mm, ICT_1.5mm, NCT_1.5mm, TCT_1.5mm). Paired <i>t</i>-test was conducted to assess the difference of spherical equivalent, axial length and choroidal thickness between mCNV group and controls. Logistic regression analysis was performed to evaluate the correlation between spherical equivalent, axial length, choroidal thickness and mCNV. <p>RESULTS: The difference of spherical equivalent and axial length between mCNV group and controls was not significant(<i>P</i>>0.05). Inferior was decreased in mCNV group compared with controls(140.85±33.46μm <i>vs</i> 168.95±45.36μm). The difference was significant(<i>P</i>=0.008). Logistic regression demonstrated that decreased choroidal thickness(ICT_1.5mm)at inferior location was associated with mCNV(<i>OR</i>=2.12; 95%<i>CI</i> 1.35～3.28; <i>P</i>=0.02). <p>CONCLUSION: The decrease of ICT_1.5MM may be one of the risk factors of mCNV