The internalization of Borrelia burgdorferi, the causative agent of Lyme disease, by phagocytes is essential for an effective activation of the immune response to this pathogen. The intracellular, cytosolic receptor Nod2 has been shown to play varying roles in either enhancing or attenuating inflammation in response to different infectious agents. We examined the role of Nod2 in responses to B. burgdorferi. In vitro stimulation of Nod2 deficient bone marrow derived macrophages (BMDM) resulted in decreased induction of multiple cytokines, interferons and interferon regulated genes compared with wild-type cells. However, B. burgdorferi infection of Nod2 deficient mice resulted in increased rather than decreased arthritis and carditis compared...
Toll-like receptors and Nod-like receptors (NLR) play an important role in sensing invading microorg...
The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an intracellular recept...
Toll-like receptors and Nod-like receptors (NLR) play an important role in sensing invading microorg...
The internalization of Borrelia burgdorferi, the causative agent of Lyme disease, by phagocytes is e...
Toll-like receptor 2 (TLR2) plays an important role in the recognition of Borrelia bacteria, the cau...
Toll-like receptor 2 (TLR2) plays an important role in the recognition of Borrelia bacteria, the cau...
<p>Activated BMDM from wild type (B6) and Nod2 deficient mice were stimulated with MDP at 100 µg/ml ...
<p>BMDM from wild type (B6) and Nod2 deficient mice were stimulated with <i>B. burgdorferi</i> at MO...
Nucleotide-binding oligomerization domain 2 (NOD2) is a cytosolic pathogen recognition receptor that...
Nod2 is a member of the NLR family of proteins that initiate inflammatory responses when exposed to ...
<p>BMDM from wild type (B6) and Nod2 deficient mice were stimulated with <i>B. burgdorferi</i> at th...
<p>Activated BMDM from wild type (B6) and Nod2 deficient mice were infected with <i>B. burgdorferi</...
BACKGROUND-AIM Leishmaniasis is a protozoan disease caused by parasites belonging to the genus Leish...
P>NOD2 of the NLRs and TLR4 of the TLRs are major pattern- recognition receptors, which sense differ...
The last decade has been witness to a number of seminal discoveries in the field of innate immunity....
Toll-like receptors and Nod-like receptors (NLR) play an important role in sensing invading microorg...
The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an intracellular recept...
Toll-like receptors and Nod-like receptors (NLR) play an important role in sensing invading microorg...
The internalization of Borrelia burgdorferi, the causative agent of Lyme disease, by phagocytes is e...
Toll-like receptor 2 (TLR2) plays an important role in the recognition of Borrelia bacteria, the cau...
Toll-like receptor 2 (TLR2) plays an important role in the recognition of Borrelia bacteria, the cau...
<p>Activated BMDM from wild type (B6) and Nod2 deficient mice were stimulated with MDP at 100 µg/ml ...
<p>BMDM from wild type (B6) and Nod2 deficient mice were stimulated with <i>B. burgdorferi</i> at MO...
Nucleotide-binding oligomerization domain 2 (NOD2) is a cytosolic pathogen recognition receptor that...
Nod2 is a member of the NLR family of proteins that initiate inflammatory responses when exposed to ...
<p>BMDM from wild type (B6) and Nod2 deficient mice were stimulated with <i>B. burgdorferi</i> at th...
<p>Activated BMDM from wild type (B6) and Nod2 deficient mice were infected with <i>B. burgdorferi</...
BACKGROUND-AIM Leishmaniasis is a protozoan disease caused by parasites belonging to the genus Leish...
P>NOD2 of the NLRs and TLR4 of the TLRs are major pattern- recognition receptors, which sense differ...
The last decade has been witness to a number of seminal discoveries in the field of innate immunity....
Toll-like receptors and Nod-like receptors (NLR) play an important role in sensing invading microorg...
The nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an intracellular recept...
Toll-like receptors and Nod-like receptors (NLR) play an important role in sensing invading microorg...