A Novel Multivariate Index for Pancreatic Cancer Detection Based On the Plasma Free Amino Acid Profile.
- Nobuyasu Fukutake
- Makoto Ueno
- Nobuyoshi Hiraoka
- Kazuaki Shimada
- Koichi Shiraishi
- Nobuhiro Saruki
- Toshifumi Ito
- Minoru Yamakado
- Nobukazu Ono
- Akira Imaizumi
- Shinya Kikuchi
- Hiroshi Yamamoto
- Kazuhiro Katayama
DOIAbstract
The incidence of pancreatic cancer (PC) continues to increase in the world, while most patients are diagnosed with advanced stages and survive <12 months. This poor prognosis is attributable to difficulty of early detection. Here we developed and evaluated a multivariate index composed of plasma free amino acids (PFAAs) for early detection of PC.We conducted a cross-sectional study in multi-institutions in Japan. Fasting plasma samples from PC patients (n = 360), chronic pancreatitis (CP) patients (n = 28), and healthy control (HC) subjects (n = 8372) without apparent cancers who were undergoing comprehensive medical examinations were collected. Concentrations of 19 PFAAs were measured by liquid chromatography-mass spectrometry. We generate...
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