Different cancer cells exhibit altered sensitivity to metformin treatment. Recent studies suggest these findings may be due in part to the common cell culture practice of utilizing high glucose, and when glucose is lowered, metformin becomes increasingly cytotoxic to cancer cells. In low glucose conditions ranging from 0 to 5 mM, metformin was cytotoxic to breast cancer cell lines MCF7, MDAMB231 and SKBR3, and ovarian cancer cell lines OVCAR3, and PA-1. MDAMB231 and SKBR3 were previously shown to be resistant to metformin in normal high glucose medium. When glucose was increased to 10 mM or above, all of these cell lines become less responsive to metformin treatment. Metformin treatment significantly reduced ATP levels in cells incubated in...
There is a great and growing interest in the anti-cancer effects of the diabetes drug metformin as e...
Metformin is proposed as adjuvant therapy in cancer treatment because of its ability to limit cancer...
Metformin is a biguanide drug that is widely used in the treatment of diabetes. Epidemiological stud...
Metformin, the most widely prescribed anti-diabetic drug, is shown to possess anti-cancer potential ...
Metformin is proposed as adjuvant therapy in cancer treatment because of its ability to limit cancer...
, in addition to inhibiting cancer cell proliferation, metformin can also induce apoptosis. The mole...
Cancer cells exhibit altered metabolism, a phenomenon described a century ago by Otto Warburg. Howev...
International audiencePrevious reports demonstrate that metformin, an anti-diabetic drug, can decrea...
<p>All cells were treated with different concentrations of metformin (0, 2, 4, 8, 16 mM) in medium c...
Abstract Emerging evidence suggests that metformin, a widely used anti-diabetic drug, may be useful ...
Metformin inhibits thyroid cancer cell growth. We sought to determine if variable glucose concentrat...
Several studies reported that metformin, the most widely used drug for type 2 diabetes, might affect...
Epidemiology studies have found that type 2 diabetics treated with metformin are at a lower risk for...
International audienceMetformin is a widely used antidiabetic agent, which regulates glucose homeost...
Previous studies suggest that metformin may exert a protective effect on cisplatin-induced cytotoxic...
There is a great and growing interest in the anti-cancer effects of the diabetes drug metformin as e...
Metformin is proposed as adjuvant therapy in cancer treatment because of its ability to limit cancer...
Metformin is a biguanide drug that is widely used in the treatment of diabetes. Epidemiological stud...
Metformin, the most widely prescribed anti-diabetic drug, is shown to possess anti-cancer potential ...
Metformin is proposed as adjuvant therapy in cancer treatment because of its ability to limit cancer...
, in addition to inhibiting cancer cell proliferation, metformin can also induce apoptosis. The mole...
Cancer cells exhibit altered metabolism, a phenomenon described a century ago by Otto Warburg. Howev...
International audiencePrevious reports demonstrate that metformin, an anti-diabetic drug, can decrea...
<p>All cells were treated with different concentrations of metformin (0, 2, 4, 8, 16 mM) in medium c...
Abstract Emerging evidence suggests that metformin, a widely used anti-diabetic drug, may be useful ...
Metformin inhibits thyroid cancer cell growth. We sought to determine if variable glucose concentrat...
Several studies reported that metformin, the most widely used drug for type 2 diabetes, might affect...
Epidemiology studies have found that type 2 diabetics treated with metformin are at a lower risk for...
International audienceMetformin is a widely used antidiabetic agent, which regulates glucose homeost...
Previous studies suggest that metformin may exert a protective effect on cisplatin-induced cytotoxic...
There is a great and growing interest in the anti-cancer effects of the diabetes drug metformin as e...
Metformin is proposed as adjuvant therapy in cancer treatment because of its ability to limit cancer...
Metformin is a biguanide drug that is widely used in the treatment of diabetes. Epidemiological stud...