Mutations and duplication/triplication of the alpha-synuclein (αSyn)-coding gene have been found to cause familial Parkinson’s disease (PD), while genetic polymorphisms in the region controlling the expression level and stability of αSyn have been identified as risk factors for idiopathic PD, pointing to the importance of wild-type (wt) αSyn dosage in the disease. Evidence that αSyn is present in the cerebrospinal fluid and interstitial brain tissue and that healthy neuronal grafts transplanted into PD patients often degenerate suggests that extracellularly-released αSyn plays a role in triggering the neurodegenerative process. αSyn’s role in neurotransmission has been shown in various cell culture models in which the protein was upregulate...
α-synuclein is a core component of Lewy bodies, one of the pathological hallmarks of Parkinson’s dis...
Alpha-synuclein is a natively unfolded protein playing a key role in the regulation of several neuro...
Synaptopathies are diseases with synapse defects as shared pathogenic features, encompassing neurode...
Mutations and duplication/triplication of the alpha-synuclein (αSyn)-coding gene have been found to ...
The aggregation of alpha synuclein (α-syn) is a neuropathological feature that defines a spectrum of...
Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and misfolded α-...
Aggregates of alpha-synuclein (αSyn) have been described in Parkinson's disease (PD) patients, and r...
Protein aggregation and accumulation are common pathological hallmarks in neurodegenerative diseases...
A unifying feature of major neurodegenerative diseases is the aggregation and deposition of misfolde...
학위논문 (석사)-- 서울대학교 대학원 : 의과학과, 2013. 8. 장성호.α-Synuclein (α-syn) can be secreted from neurons into the...
Alpha-synuclein is a presynaptic protein expressed throughout the central nervous system, and it is ...
: The critical role of alpha-synuclein in Parkinson's disease represents a pivotal discovery. Some p...
The protein alpha-synuclein (α-syn) is by far the most vetted pathogenic participant in the neurodeg...
Alpha-synuclein (alpha-syn) is a small soluble protein expressed primarily at presynaptic terminals ...
Neurodegenerative diseases are characterized by the accumulation and aggregation of particular prote...
α-synuclein is a core component of Lewy bodies, one of the pathological hallmarks of Parkinson’s dis...
Alpha-synuclein is a natively unfolded protein playing a key role in the regulation of several neuro...
Synaptopathies are diseases with synapse defects as shared pathogenic features, encompassing neurode...
Mutations and duplication/triplication of the alpha-synuclein (αSyn)-coding gene have been found to ...
The aggregation of alpha synuclein (α-syn) is a neuropathological feature that defines a spectrum of...
Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and misfolded α-...
Aggregates of alpha-synuclein (αSyn) have been described in Parkinson's disease (PD) patients, and r...
Protein aggregation and accumulation are common pathological hallmarks in neurodegenerative diseases...
A unifying feature of major neurodegenerative diseases is the aggregation and deposition of misfolde...
학위논문 (석사)-- 서울대학교 대학원 : 의과학과, 2013. 8. 장성호.α-Synuclein (α-syn) can be secreted from neurons into the...
Alpha-synuclein is a presynaptic protein expressed throughout the central nervous system, and it is ...
: The critical role of alpha-synuclein in Parkinson's disease represents a pivotal discovery. Some p...
The protein alpha-synuclein (α-syn) is by far the most vetted pathogenic participant in the neurodeg...
Alpha-synuclein (alpha-syn) is a small soluble protein expressed primarily at presynaptic terminals ...
Neurodegenerative diseases are characterized by the accumulation and aggregation of particular prote...
α-synuclein is a core component of Lewy bodies, one of the pathological hallmarks of Parkinson’s dis...
Alpha-synuclein is a natively unfolded protein playing a key role in the regulation of several neuro...
Synaptopathies are diseases with synapse defects as shared pathogenic features, encompassing neurode...