Cobalt chromium (CoCr) alloy and stainless steel are widely used in orthopaedic implants. Cr(VI) is known to be released when metals corrode in vivo (Milošev et al., 2005) and may be toxic to local cells like osteoblasts and macrophages. Ning and Grant, 2000 J. Ning and M.H. Grant, Toxicol. In Vitro 14 (2000), pp. 329-335. Article | PDF (185 K) | View Record in Scopus | Cited By in Scopus (25)Ning and Grant (2000) have demonstrated the acute toxicity of Cr(VI) to immortalised rat osteoblasts and shown the involvement of reduced glutathione (GSH) and glutathione reductase (GRd) in the interaction. The aim of this study was to investigate the chronic effects of exposure to clinically relevant Cr(VI) concentrations on the human monocyte cell l...