BACKGROUND:Very recently, a novel type 2 diabetes risk gene, i.e., MTNR1B, was identified and reported to affect fasting glycemia. Using our thoroughly phenotyped cohort of subjects at an increased risk for type 2 diabetes, we assessed the association of common genetic variation within the MTNR1B locus with obesity and prediabetes traits, namely impaired insulin secretion and insulin resistance. METHODOLOGY/PRINCIPAL FINDINGS:We genotyped 1,578 non-diabetic subjects, metabolically characterized by oral glucose tolerance test, for five tagging single nucleotide polymorphisms (SNPs) covering 100% of common genetic variation (minor allele frequency > 0.05) within the MTNR1B locus (rs10830962, rs4753426, rs12804291, rs10830963, rs3781638). In a...
Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) ...
<div><h3>Introduction</h3><p>Single nucleotide polymorphisms (SNPs) in approximately 40 genes have b...
OBJECTIVE—Several single nucleotide polymorphisms (SNPs) in diabetes risk genes reduce glucose- and/...
BACKGROUND: Type 2 diabetes arises when insulin resistance-induced compensatory insulin secretion ex...
OBJECTIVE-Recently, results from a meta-analysis of genome-wide association studies have yielded a n...
Although type 2 diabetes (T2D) results from metabolic defects in insulin secretion and insulin sensi...
BACKGROUND: Previous studies identified melatonin receptor 1B (MTNR1B), islet-specific glucose 6 pho...
To identify previously unknown genetic loci associated with fasting glucose concentrations, we exami...
To identify previously unknown genetic loci associated with fasting glucose concentrations, we exami...
Patients with established type 2 diabetes display both b-cell dysfunction and insulin resistance. To...
Common genetic variants have been recently associated with fasting glucose and insulin levels in whi...
<div><h3>Background</h3><p>Melatonin receptor 1B (MTNR1B) belongs to the seven-transmembrane G prote...
BACKGROUND: Melatonin receptor 1B (MTNR1B) belongs to the seven-transmembrane G protein-coupled rece...
In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs138715...
Published onlineJournal ArticleThis is the author accepted manuscript. The final version is availabl...
Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) ...
<div><h3>Introduction</h3><p>Single nucleotide polymorphisms (SNPs) in approximately 40 genes have b...
OBJECTIVE—Several single nucleotide polymorphisms (SNPs) in diabetes risk genes reduce glucose- and/...
BACKGROUND: Type 2 diabetes arises when insulin resistance-induced compensatory insulin secretion ex...
OBJECTIVE-Recently, results from a meta-analysis of genome-wide association studies have yielded a n...
Although type 2 diabetes (T2D) results from metabolic defects in insulin secretion and insulin sensi...
BACKGROUND: Previous studies identified melatonin receptor 1B (MTNR1B), islet-specific glucose 6 pho...
To identify previously unknown genetic loci associated with fasting glucose concentrations, we exami...
To identify previously unknown genetic loci associated with fasting glucose concentrations, we exami...
Patients with established type 2 diabetes display both b-cell dysfunction and insulin resistance. To...
Common genetic variants have been recently associated with fasting glucose and insulin levels in whi...
<div><h3>Background</h3><p>Melatonin receptor 1B (MTNR1B) belongs to the seven-transmembrane G prote...
BACKGROUND: Melatonin receptor 1B (MTNR1B) belongs to the seven-transmembrane G protein-coupled rece...
In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs138715...
Published onlineJournal ArticleThis is the author accepted manuscript. The final version is availabl...
Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) ...
<div><h3>Introduction</h3><p>Single nucleotide polymorphisms (SNPs) in approximately 40 genes have b...
OBJECTIVE—Several single nucleotide polymorphisms (SNPs) in diabetes risk genes reduce glucose- and/...